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The relationship between histamine receptor type 4 gene polymorphism (rs11662595) and response to H1 antihistamine drugs in patients with chronic idiopathic urticaria
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Ebrahim Mohammadi1    , Fakhredin Karimpour2 , Ramin Lotfi3 , Fatemeh Zamani4 , Abbas Aghaei5 , Rasoul Nasiri Kalmarzi6 |
1- Kurdistan University of Medical Sciences & Assistant Professor, Environmental Health Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran
2- Kurdistan University of Medical Sciences & Department of Occupational Health Engineering, Faculty of Health, Kurdistan University of Medical Sciences, Sanandaj, Iran
3- Kurdistan University of Medical Sciences & Pediatrician, Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran
4- Kurdistan University of Medical Sciences & MSc of Medical Immunology, Lung Diseases and Allergy Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran
5- Kurdistan University of Medical Sciences & Assistant Professor, Cancer and Immunology Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran
6- Kurdistan University of Medical Sciences & Associate Professor, Lung Diseases and Allergy Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran , rasool_nsr@yahoo.com |
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Abstract: (1453 Views) |
Background and Aim Chronic urticaria is a common allergic skin disease that is characterized by itching and hives, with or without angioedema, that persist for more than 6 weeks. This study aimed to investigate the genetic frequency of the histamine receptor 4 gene polymorphism at SNP rs11662595 in individuals with chronic urticaria and their response to antihistamine treatment and side effects.
Materials and Methods 130 patients with confirmed chronic idiophatic urticaria (CIU) and no other infectious or inflammatory diseases were selected for this study. With the consent of the patients, 5 ml of peripheral blood was taken from each patient for DNA extraction (in a CBC tube) and IgE measurement (in a hemolysis tube without anticoagulant). Genotyping of rs11662595 SNP was determined by PCR-RFLP and total IgE serum level was measured by ELISA method. The disease severity score in the first and twelfth weeks after treatment and the side effects of antihistamine drugs were determined for all patients.
Results: The frequency of rs11662595 polymorphism of HRH4 gene in chronic urticaria patients and healthy control participating in the study was calculated as 17.7% and 18.6%, respectively. However, according to the follow-up during 12 weeks, chronic urticaria patients who had the rs11662595 variant of the HRH4 gene did not show a different response to antihistamine treatment than those without the variant. The only variable that was significantly higher in people with the HRH4 gene variant than in people without this variant was the serum level of D-dimer.
Conclusion: Considering that there was no difference between patients with normal SNP and HRH4 gene polymorphism in any of the examined parameters, it is not important in the response to H1 antihistamine drugs. To find individual genetic responses to antihistamine drugs, other genes involved in the response to these drugs should be examined. |
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| Keywords: Chronic urticaria, antihistamine drugs, histamine receptor, polymorphism |
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Full-Text [PDF 539 kb]
(252 Downloads)
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Type of Study: Original Research |
Subject:
Medicine - Pediatric
Received: 2022/10/14 | Accepted: 2024/04/16 | Published: 2024/10/29
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Ethics code: IR.MUK.REC.1401.097
Mohammadi E, Karimpour F, Lotfi R, Zamani F, Aghaei A, Nasiri Kalmarzi R. The relationship between histamine receptor type 4 gene polymorphism (rs11662595) and response to H1 antihistamine drugs in patients with chronic idiopathic urticaria. SJKU 2024; 29 (4) :39-48 URL: http://sjku.muk.ac.ir/article-1-7621-en.html
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