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:: Scientific Journal of Kurdistan University of Medical Sciences- NO 4, 2024 -Articles In press ::
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The relationship between histamine receptor type 4 gene polymorphism (rs11662595) and response to H1 antihistamine drugs in patients with chronic idiopathic urticaria
Ebrahim Mohammadi1 , Fakhredin Karimpour1 , Ramin Lotfi1 , Fatemeh Zamani1 , Abbas Aghaei1 , Rasoul Nasiri Kalmarzi 2
1- Kurdistan University of Medical Sciences
2- Kurdistan University of Medical Sciences , rasool_nsr@yahoo.com
Abstract:   (207 Views)
Background and Aim Chronic urticaria is a common allergic skin disease that is characterized by itching and hives, with or without angioedema, that persist for more than 6 weeks. The aim of this study was to investigate the genetic frequency of the histamine receptor 4 gene plymorphism at SNP rs11662595 in individuals with chronic urticaria and their response to antihistamine treatment and side effects.
Materials and Methods 130 patients with confirmed chronic idiophatic urticaria (CIU) and no other infectious or inflammatory diseases were selected for this study. With the consent of the patients, 5 ml of peripheral blood was taken from each patient for DNA extraction (in a CBC tube) and IgE measurement (in a hemolysis tube without anticoagulant). Genotyping of rs11662595 SNP was determined by PCR-RFLP and total IgE serum level was measured by ELISA method. The disease severity score in the first and twelfth weeks after treatment and the side effects of antihistamine drugs were determined for all patients.

Results: The frequency of rs11662595 polymorphism of HRH4  gene in chronic urticaria patients and healthy control participating in the study was calculated as 17.7% and 18.6%, respectively. However, according to the follow-up during 12 weeks, chronic urticaria patients who had the rs11662595 variant of the HRH4  gene did not show a different response to antihistamine treatment than those without the variant. The only variable that was significantly higher in people with the HRH4  gene variant than in people without this variant was the serum level of D-dimer.
Conclusion: Considering that there was no difference between patients with normal SNP and HRH4  gene polymorphism in any of the examined parameters, it is not important in the response to H1 antihistamine drugs. To find individual genetic responses to antihistamine drugs, other genes involved in the response to these drugs should be examined.
 
Keywords: Chronic urticaria, antihistamine drugs, histamine receptor, polymorphism
     
Type of Study: Original Research | Subject: Medicine - Pediatric
Received: 2022/10/14 | Accepted: 2024/04/16
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Ethics code: IR.MUK.REC.1401.097


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مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
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