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Central Library of Kurdistan University of Medical Sciences
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:: Volume 28, Issue 4 (Scientific Journal of Kurdistan University of Medical Sciences 2023) ::
SJKU 2023, 28(4): 24-38 Back to browse issues page
Comparison of the Antidiabetic Activity of Lepidium sativum Seed Extract with that of Insulin in Diabetic Rats: A Comparative Study
Mehran Kamani1 , Sara Hookari2 , Hossein Nikzad 3
1- Assistant Professor of Anatomical Sciences, Sirjan School of Medical Sciences, Sirjan, Iran
2- Frarabi Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.
3- Gametogenesis Research Center, Kashan University of Medical Sciences, Kashan, Iran , hnikzad@yahoo.com
Abstract:   (1080 Views)
Background and Aim: Diabetes can adversely affect spermatogenesis. Garden cress plant, known as Lepidium sativum, contains antioxidants. This study aimed to evaluate and compare in vivo antidiabetic activities of hydroalcoholic garden cress seed extract and insulin on diabetic rats.
Material and Methods: In this experimental study, diabetes was induced in the animals using streptozotocin (STZ; 60 mg/kg). Fifty rats were divided into five equal groups as follows: Groups 1, nondiabetic rats; group 2, diabetic rats induced by streptozotocin; Group 3, diabetic animals that received streptozotocin plus insulin; and groups 4 and 5 were diabetic rats that received 200 and 400 mg/kg garden cress seed extract respectively by gavage for 4 weeks. At the end of the study, the sperm parameters obtained from the tail of the left epididymis and biochemical parameters were analyzed and compared among the groups. Data were analyzed by one-way ANOVA.
Results: The sperm parameters of the diabetic groups receiving 200 and 400 mg/kg of garden cress extract demonstrated a significant increase in all parameters compared to those of the diabetic control group. Administration of garden cress extract as a powerful antioxidant led to compensation for the streptozotocin toxicity and improved sperm quality.
Conclusion: Administration of the Lepidium sativum seed extract compensated for the Streptozotocin-induced harmful effects. Our findings suggested that use of the garden cress seed extract and insulin therapy may have a potential protective effect on diabetes mellitus.
Keywords: Antioxidants, Diabetes, Insulin, Lepidium sativum
Full-Text [PDF 820 kb]   (308 Downloads)    
Type of Study: Original Research | Subject: General
Received: 2022/05/30 | Accepted: 2022/09/26 | Published: 2023/09/27
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kamani M, Hookari S, Nikzad H. Comparison of the Antidiabetic Activity of Lepidium sativum Seed Extract with that of Insulin in Diabetic Rats: A Comparative Study. SJKU 2023; 28 (4) :24-38
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Volume 28, Issue 4 (Scientific Journal of Kurdistan University of Medical Sciences 2023) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
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