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Association study of rs1632943 and rs1736932 polymorphisms of the HLA-G gene with recurrent abortion in the northwest women of Iran
Baharak Ebrahimi Behnam1 , Mohammad Khalaj kondori 2, Mohammad ali Hoseinpour Feizi1
1- University of Tabriz
2- University of Tabriz , khalaj49@gmail.com
Abstract:   (70 Views)
Background and purpose: Recurrent spontaneous abortion (RSA) is the most common complication of pregnancy that refers to two or more miscarriages before the 20th week of pregnancy.HLA-G immunoglobulin molecule plays an important role in protecting the fetus against the motherchr('39')s immune system . The aim of this study was to investigate the association between rs1632943 and rs1736932 polymorphisms with recurrent spontaneous abortion in northwestern Iran.
 Materials and methods: In this case-control study, 100 women with history of RSA as a case group and 80 healthy women with one or more than one children as the control group were included. Genomic DNA was purified from their peripheral blood samples and their genotypes were identified using PCR-sequencing method. Statistical analysis was performed by chi-square test using SPSS 16.
Results: In the rs1632943 polymorphism the frequency of CC, CA and AA genotypes were 8%, 33% and 59% in the patient group and 16.25%, 43.75% and % 40 in the control group, respectively. statistical analysis showed that AA genotype was associated with the recurrent miscarriage (P = 0.005). In the rs1736932 polymorphism, the frequency of CC, CG and GG genotypes were 8%, 32% and 60% in patient group and 17.5%, 41.25% and 41.25% in control group, respectively. Statistical analysis showed that AA genotype was associated with the recurrent miscarriage (P = 0.005)Also, haplotype analysis showed that H1 haplotype (GA) is associated with the disease.
Conclusion: Results of present study highlighted that rs1632943 and ra1736932 polymorphisms might be considered as a risk factor for RSA in the northwestern Iranian women.            
 
Keywords: HLA-G, recurrent spontaneous abortion, single-nucleotide polymorphism
     
Type of Study: Research | Subject: Molecular Medicine and Genetics
Received: 2020/01/21 | Accepted: 2020/12/20
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مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
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