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The association between RNASEL R462Q polymorphism and prostate cancer
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Mohammad Ali Rezaee1   , Worya Hossaini2 , Bahram Nikkhoo3 , Mazaher Khodabandeloo4 , Mohammad Reza Rahmani5 |
1- Zoonoses Research center, Kurdistan University of Medical Sciences, Sanandaj, Iran.
2- Department of Immunology and Hematology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.
3- Cellular and Molecular Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran
4- Department of Microbiology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.
5- Zoonoses Research center, Kurdistan University of Medical Sciences, Sanandaj, Iran. , rahmany191@gmail.com |
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Abstract: (5351 Views) |
Background and Aim: RNase L is a cytoplasmic enzyme of the innate immune system that destroys RNA viruses and also plays an important role in the apoptosis of different cells. The association of ribonuclease L (RNASEL) gene polymorphisms with susceptibility to prostate cancer in different populations has been reported. In this study, the association of RNase L R462Q single nucleotide polymorphism (SNP) and prostate cancer was investigated in Sanandaj City in Iran.
Material and Methods: This case-control study included 61 men with confirmed prostate cancer as our case group and 101 men with benign prostatic hyperplasia (BPH) as control group. The genomic DNA from prostate tissue samples were obtained from both groups and were embedded in paraffin blocks. The prevalence of the polymorphism of RNASEL gene in R462Q location was determined by using Amplification-Refractory Mutation System PCR (ARMS-PCR). Data were analyzed by chi-square test.
Results: The mean age was 70.12±13.37 years for the patients with cancer and 71.05±9.26 years for the control group (P=0.6). The frequencies of GG and GA genotypes in the two groups were not different significantly (p>0.05). The frequencies of AA genotype in the patients with cancer and control group were 18.03% and 5.94% respectively (p= 0.02, OR= 3.48, CI: 1.46-15.2).
Conclusion: The results of this study indicated that AA genotype polymorphism of RNASEL gene in R462Q location was associated with increased susceptibility to prostate cancer.
Keywords: RNASEL, R462Q, Polymorphism, Prostate cancer, Benign Prostatic Hyperplasia.
Received: Oct 23, 2016 Accepted: Feb 6, 2017 |
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| Keywords: RNASEL, R462Q, Polymorphism, Prostate cancer, Benign Prostatic Hyperplasia. |
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Full-Text [PDF 2652 kb]
(1165 Downloads)
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Type of Study: Original Research |
Subject:
General
Received: 2017/07/24 | Accepted: 2017/07/24 | Published: 2017/07/24
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