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Comparison of the effect before and after intracorpus cavernosum Platelet-rich plasma injection in imporoving sexual function in men with erectile dysfunction
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Peyman Hayati1    , Rezgar Daneshdoost2 , Pouya Fattahi3 , Khaled Rahmani4 |
1- Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran , peymanhayati1995@gmail.com
2- Department of Urology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran
3- Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran
4- Social Determinants of Health Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran |
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Abstract: (362 Views) |
Background and Aim: Erectile dysfunction (ED) is a common problem among males, and the use of platelet-rich plasma (PRP) therapy for the treatment of ED has attracted increasing attention; however, there is still no definitive evidence of its effectiveness. This study aimed to compare sexual function before and after intracavernosal platelet-rich plasma (PRP) injection in men with erectile dysfunction.
Materials and methods: This single-arm, before-and-after interventional study without any randomization was conducted on 32 men with erectile dysfunction who were referred to Kowsar Hospital in Sanandaj, Iran. In this study, after completing demographic characteristics, their sexual dysfunction score was measured using the International Index of Erectile Function (IIEF) questionnaire. Then, the PRP subjects filled out the questionnaire on days 0, 20, 40, and 60 after receiving each PRP injection. Evaluation of outcome indicators 20 days later, 40 days later, and 60 days after receiving PRP was performed. The most important outcome indicator is the sexual function of the patients, which was measured using the IIEF. For data analysis, considering the qualitative nature of the dependent variable, t-test, chi-square, and logistic regression tests were used. For all tests, a significance level of 0.05 was considered.
Results: According to the results, the mean age of the patients was 57.31 years. The results showed that the mean total score was 7.43 ± 2.63 before injection, 9.87 ± 3.53 at 20 days after injection, 10.81 ± 3.52 at 40 days after injection, and 11.46 ± 3.81 at 60 days after injection. The analytical results showed a significant difference between the score of sufficient erection before and after injection (days 20, 40, 60 ), sufficient erection for penetration, sufficient erection after penetration before injection, and 20 days after injection. There was also a significant difference between the mean total score before and after injection (days 20, 40, and 60), and it seems that intracorpus cavernosum PRP injection had a significant effect on restoring normal erectile function and satisfaction with sexual function of the subjects studied (P<0.0001). However, no statistically significant difference was observed in the score for maintaining an erection until completion of intercourse before and after the injection (P>0.05).
Conclusion: PRP treatment for erectile dysfunction has shown promising efficacy and has the potential to become a new alternative treatment option for patients with erectile dysfunction. |
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| Keywords: Erectile dysfunction, Intracorpus cavernosum injection, PRP, Sexual function |
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Full-Text [PDF 817 kb]
(73 Downloads)
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Type of Study: Original Research |
Subject:
Medicine - Urology
Received: 2026/06/8 | Accepted: 2026/08/10 | Published: 2026/09/8
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