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Comparative study of mean serum D-dimer level in children with urinary tract infection and healthy children
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Abstract: (58 Views) |
Background and Aim: Urinary tract infection is a common disease in children and may be associated with complications, such as late renal scarring. Given the increase in D-dimer in infection and its potential to distinguish it from non-infectious cases, this study was conducted to determine and compare mean serum D-dimer levels in healthy children and children with urinary tract infections.
Methods: This case-control study was conducted on 130 children in two groups (65 children with culture-confirmed urinary tract infections and 65 healthy children) in 2021. In this study, demographic characteristics, CBC findings, and D-dimer levels were examined and finally subjected to statistical analysis.
Results: The findings of this study showed that the mean age of the group of children with UTI was 4.42 ± 3.32 years, and in the group of healthy children was 5.35 ± 2.80 years. Moreover, the mean age of the total subjects was 4.88± 3.10 years. Furthermore, most of the subjects in the group of children with urinary tract infections and healthy children were girls (with a frequency of 78.46% and 60%, respectively). The WBC level in children with urinary tract infections was significantly higher than that in healthy children (P<0.001). The mean D-dimer level in children with UTI was also significantly higher than that in healthy children (P<0.001). However, there was no significant difference in HB and PLT levels.
Conclusions: According to the results of this study in children with UTI aged 1 month to 15 years, D-dimer levels are significantly higher than those in healthy children. Therefore, D-dimer levels can be considered a potential diagnostic marker of UTI in children. |
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| Keywords: Children, D-dimer, Pyelonephritis, Urinary tract infection |
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Full-Text [PDF 830 kb]
(27 Downloads)
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Type of Study: Original Research |
Subject:
Medicine - Pediatric
Received: 2025/01/20 | Accepted: 2026/07/30 | Published: 2026/09/26
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