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Resistance to Ciprofloxacin and Levofloxacin fluoroquinolones in Extended-Spectrum Beta-Lactamase-Producing Klebsiella pneumoniae Isolates in Sanandaj Health Centers
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Hedayat Bozorgi mohajer1    , Jalileh Ebn Abbas2 , Arian Azadnia3 |
1- Master of Medical Microbiology, Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran , hedayatbozorgy@gmail.com
2- Master of Medical Microbiology, Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran
3- Master of Epidemiology, Research Center for Social Factors Affecting Health, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran |
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Abstract: (936 Views) |
Background and Aim: One of the most important bacterial resistance mechanisms is production of Extended-Spectrum Beta-Lactamase (ESBL). In addition, ESBL strains usually have resistance to several antibiotic classes, because multiple resistance genes are often carried by a plasmid. One of these multiple resistances is the simultaneous resistance to quinolones and ESBL production. The aim of this study was to determine the prevalence of resistance to fluoroquinolones in ESBL-producing Klebsiella pneumoniae isolates in Sanandaj health centers in 2018.
Materials and Methods: Evaluation of antibiotic susceptibility in all isolates (phenotypically and at Minimum inhibitory concentration (MIC) and identification of ESBL strains were performed by VITEK2. We evaluated the relationship between ESBL production and resistance to fluoroquinolones (ciprofloxacin and levofloxacin) by statistical tests.
Results: According to the antibiotic susceptibility results of 67 isolates, 35 isolates (52.23%) were resistant to ciprofloxacin and levofloxacin. 25 isolates (37.31%) were identified as ESBL, of which 19 isolates (76%) were resistant to levofloxacin and ciprofloxacin and only 6 isolates (24%) were sensitive to these antibiotics. Statistical analysis showed that resistance to ciprofloxacin and levofloxacin was significantly increased in ESBL isolates compared to that in non-ESBL isolates (P-value = 0.003).
Conclusions: In this study, simultaneous resistance to fluoroquinolones (ciprofloxacin and levofloxacin) and ESBL production was observed in Klebsiella pneumoniae isolates, which can limit treatment options. Also, the results of this study showed that the treatment of the ESBL Klebsiella pneumoniae infection with levofloxacin and ciprofloxacin antibiotics will be a challenge in these medical centers.
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| Keywords: Klebsiella pneumoniae, ESBL, Ciprofloxacin, Levofloxacin |
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Full-Text [PDF 438 kb]
(321 Downloads)
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Type of Study: Original Research |
Subject:
Microbiology
Received: 2022/11/26 | Accepted: 2023/09/5 | Published: 2024/07/10
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Ethics code: IR.MUK.REC.1397/372
bozorgi mohajer H, Ebn Abbas J, Azadnia A. Resistance to Ciprofloxacin and Levofloxacin fluoroquinolones in Extended-Spectrum Beta-Lactamase-Producing Klebsiella pneumoniae Isolates in Sanandaj Health Centers. SJKU 2024; 29 (2) :47-55 URL: http://sjku.muk.ac.ir/article-1-7695-en.html
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