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:: Volume 28, Issue 5 (Scientific Journal of Kurdistan University of Medical Sciences 2023) ::
SJKU 2023, 28(5): 25-36 Back to browse issues page
Effect of Hydroalcoholic Extract of Anethum graveolens Seed on Lipopolysaccharide-Induced Liver Damage in the Rat
Ahmad Changaee1 , Mohammad Hassan Ghosian Moghadam2 , Mahsa Tashakori-Miyanroudi3 , Mehrdad Roghani 4
1- Faculty of Medicine, Shahed University, Tehran, Iran.
2- Department of Biochemistry, Faculty of Medicine, Shahed University, Tehran, Iran
3- Department of Physiology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
4- Neurophysiology Research Center, Shahed University, Tehran, Iran. , mroghani@shahed.ac.ir
Abstract:   (453 Views)
Background and Aim: Oxidative stress and inflammatory response play an important role in the development of lipopolysaccharide (LPS)-induced acute liver dysfunction. The purpose of this study was to investigate the effect of hydroalcoholic extract of dill seed on liver damage induced by LPS.
Materials and Methods: In this study, 32 rats weighing between 200 and 250 g were divided into four groups: control, control treated with dill hydroalcoholic extract, rats with liver damage، and rats with liver damage treated with dill hydroalcoholic extract. Dill hydroalcoholic extract was administered at a dose of 200 mg/kg. LPS was used to induce liver damage. Activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), superoxide dismutase (SOD), and catalase level of malondialdehyde (MDA) and tumor necrosis factor a (TNF-α) were measured. The differences between groups were analyzed using one-way ANOVA and Tukey's tests.
Results: The levels of ALT, AST, ALP, TNF-α and MDA significantly increased and activities of SOD and catalase significantly decreased in the LPS group compared to those in the control group. Treatment with hydroalcoholic extract of dill significantly decreased ALT, AST, ALP, TNF-α and MDA and significantly increased SOD activity compared to those in the LPS group.
Conclusion: Hydroalcoholic extract of dill showed a protective effect against liver dysfunction caused by LPS which is due to its anti-inflammatory and antioxidant properties.
 
Keywords: Lipopolysaccharide, Liver, Anethum graveolens, Oxidative stress, Inflammation
Full-Text [PDF 884 kb]   (94 Downloads)    
Type of Study: Original Research | Subject: Physiology and neurosciences
Received: 2022/07/30 | Accepted: 2023/02/13 | Published: 2023/12/6
References
1. Hu J-j, Wang H, Pan C-w, Lin M-xJMP. Isovitexin alleviates liver injury induced by lipopolysaccharide/d-galactosamine by activating Nrf2 and inhibiting NF-κB activation. Microb Pathog. 2018;119:86-92. [DOI:10.1016/j.micpath.2018.03.053] [PMID]
2. Ore A, Ugbaja RN, Adeogun AI, Akinloye OA. Hydroethanolic extract of Buchholzia coriacea seeds alleviates LPS induced liver injury in rat via antioxidant and anti-inflammatory actions. J Complement Altern Med Res. 2019;8:1-15. [DOI:10.9734/jocamr/2019/v8i230116]
3. Rosenberg WM, Voelker M, Thiel R, Becka M, Burt A, Schuppan D, et al. Serum markers detect the presence of liver fibrosis: a cohort study. Gastroenterology 2004;127(6):1704-13. [DOI:10.1053/j.gastro.2004.08.052] [PMID]
4. Vaara M. Lipopolysaccharide and the permeability of the bacterial outer membrane. Endotoxin in health and disease: CRC Press; 2020. p. 31-8. [DOI:10.1201/9781003064961-2]
5. Latha S, Chaudhary S, Ray RJB, Pharmacotherapy. Hydroalcoholic extract of Stevia rebaudiana bert. leaves and stevioside ameliorates lipopolysaccharide induced acute liver injury in rats. Biomed Pharmacother. 2017;95:1040-50. [DOI:10.1016/j.biopha.2017.08.082] [PMID]
6. Li F, Liao X, Jiang L, Zhao J, Wu S, Ming J. Orientin Attenuated d-GalN/LPS-Induced Liver Injury through the Inhibition of Oxidative Stress via Nrf2/Keap1 Pathway. J Agric Food Chem. 2022;70(26):7953-7967. [DOI:10.1021/acs.jafc.2c02015] [PMID]
7. Sajedianfard J, Behroozi Z, Nazifi S. The effects of a hydroalcoholic extract of silymarin on serum lipids profiles in streptozotocin induced diabetic rats. Comp Clin Path. 2014;23(3):779-788 [DOI:10.1007/s00580-013-1688-6]
8. Sajedianfard J, Behroozi Z, Nazifi S, Rajaian H. The effect of different oral doses of hydroalcoholic extract of silymarin on the blood oxidative stress indicators in streptozotocin induced diabetic rats. Int J Pept Res Ther. 2013;19(2):93-8. [DOI:10.1007/s10989-012-9318-8]
9. El Mansouri L, Bousta D, El Youbi-El Hamsas A, Boukhira S, Akdime H. Phytochemical screening, antidepressant and analgesic effects of aqueous extract of Anethum graveolens L. from southeast of Morocco. Am J Ther. 2016;23(6):e1695-e1699. [DOI:10.1097/MJT.0000000000000090] [PMID]
10. Abbasi Oshaghi E, Khodadadi I, Saidijam M, Yadegarazari R, Shabab N, Tavilani H, et al. Lipid lowering effects of hydroalcoholic extract of Anethum graveolens L. and dill tablet in high cholesterol fed hamsters. Cholesterol. 2015;2015: 958560. [DOI:10.1155/2015/958560] [PMID] []
11. Mirhosseini M, Baradaran A, Rafieian-Kopaei M. Anethum graveolens and hyperlipidemia: A randomized clinical trial. J Res Med Sci. 2014;19(8):758-61.
12. Abbasi Oshaghi E, Khodadadi I, Saidijam M, Yadegarazari R, Shabab N, Tavilani H, et al. Lipid Lowering Effects of Hydroalcoholic Extract of Anethum graveolens L. and Dill Tablet in High Cholesterol Fed Hamsters. Cholesterol. 2015;2015:958560. [DOI:10.1155/2015/958560] [PMID] []
13. Ou TT, Kuo CY, Chyau CC, Lee HJ, Peng JS, Wang CJ. Improvement of lipopolysaccharide-induced hepatic injuries and inflammation with mulberry extracts. J Sci Food Agric. 2013 ;93(8):1880-86.. [DOI:10.1002/jsfa.5984] [PMID]
14. Baluchnejadmojarad T, Zeinali H, Roghani M. Scutellarin alleviates lipopolysaccharide-induced cognitive deficits in the rat: Insights into underlying mechanisms. Int Immunopharmacol. 2018;54:311-319. [DOI:10.1016/j.intimp.2017.11.033] [PMID]
15. Pourmohammadi S, Roghani M, Kiasalari Z, Khalili M. Paeonol Ameliorates Cuprizone-Induced Hippocampal Demyelination and Cognitive Deficits through Inhibition of Oxidative and Inflammatory Events. J Mol Neurosci. 2022;72(4):748-58. [DOI:10.1007/s12031-021-01951-2] [PMID]
16. Moloudi MR, Hassanzadeh K, Rouhani S, Zandi F, Ahmadi A, Khalwatian P, et al. Effect of chloroformic extract of Cichorium intybus on liver function tests and serum level of TNF-α in obstructive cholestasis in rat. Scientific Journal of Kurdistan University of Medical Sciences. 2014;19(4):10-19.
17. Beheshti F, Norouzi F, Abareshi A, Khazaei M, Alikhani V, Moussavi S, et al. Nigella sativa prevented liver and renal tissue damage in lipopolysaccharide-treated rats. 2018;29(3):554-566. [DOI:10.4103/1319-2442.235184] [PMID]
18. Xu Q, Xu J, Zhang K, Zhong M, Cao H, Wei R, et al. Study on the protective effect and mechanism of Dicliptera chinensis (L.) Juss (Acanthaceae) polysaccharide on immune liver injury induced by LPS. Biomed Pharmacother. 2021;134:111159. [DOI:10.1016/j.biopha.2020.111159] [PMID]
19. Mohamadin AM, Elberry AA, Elkablawy MA, Gawad HSA, Al-Abbasi FA. Montelukast, a leukotriene receptor antagonist abrogates lipopolysaccharide-induced toxicity and oxidative stress in rat liver. Pathophysiology. 2011;18(3):235-42. [DOI:10.1016/j.pathophys.2011.02.003] [PMID]
20. Nowak M, Gaines GC, Rosenberg J, Minter R, Bahjat F, Rectenwald J, et al. LPS-induced liver injury ind-galactosamine-sensitized mice requires secreted TNF-α and the TNF-p55 receptor. Am J Physiol Regul Integr Comp Physiol. 2000;278(5):R1202-R9. [DOI:10.1152/ajpregu.2000.278.5.R1202] [PMID]
21. Stigger F, Lovatel G, Marques M, Bertoldi K, Moysés F, Elsner V, et al. Inflammatory response and oxidative stress in developing rat brain and its consequences on motor behavior following maternal administration of LPS and perinatal anoxia. Int J Dev Neurosci. 2013;31(8):820-27. [DOI:10.1016/j.ijdevneu.2013.10.003] [PMID]
22. Rabeh NM, Aboraya AO.. Hepatoprotective effect of dill (Anethum graveolens L.) and fennel (Foeniculum vulgare) oil on hepatotoxic rats. Pakistan Journal of Nutrition. 2014;13(6):303-309. [DOI:10.3923/pjn.2014.303.309]
23. Ali WSH. Hypolipidemic and antioxidant activities of Anethum graveolens against acetaminophen induced liver damage in rats. World Journal of Medical Sciences. 2013;8(4):387-92.
24. El-Maghraby S, Taha H, Hassan NS. Effect of Anthum graveolens extract on biochemical and histopathological alteration of deltamethrin in rats. Journal of Bioanalysis & Biomedicine 2010;2(1):8-12. [DOI:10.4172/1948-593X.1000014]
25. Yousaf A, Shahid S. The study of Anethum graveolens L. (Dill) in the case of Diabetes mellitus (DM). 2020;10(4):248-56. [DOI:10.5958/2231-5659.2020.00045.4]
26. KORKMAZ S, Koç F. The protective effects of dill (Anethum graveolens L.) in paracetamol-induced acute toxication in mice. Int J Agric Sci..2021;14(1):47-60.
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Changaee A, Ghosian Moghadam M H, Tashakori-Miyanroudi M, Roghani M. Effect of Hydroalcoholic Extract of Anethum graveolens Seed on Lipopolysaccharide-Induced Liver Damage in the Rat. SJKU 2023; 28 (5) :25-36
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Volume 28, Issue 5 (Scientific Journal of Kurdistan University of Medical Sciences 2023) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
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