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The association between vascular endothelial growth factor gene polymorphism (VEGF-2578 C/A; rs699947) and lipid profile in Iranian patients with rheumatoid arthritis
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Akram Rostamzadeh1    , Ebrahim Mohammadi2 , Khaled Rahmani3 , Ali Jalili4 , Borhan Moradveisi4 , Nasrin Moghimi5 |
1- Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran
2- Environmental Health Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran
3- Liver and Digestive Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran
4- Cancer and Immunology Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran
5- Department of Internal Medicine, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran , @yahoo.com |
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Abstract: (11 Views) |
Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease with a genetic and environmental etiology. Evidence suggests an increased risk of atherosclerosis and its associated mortality in patients with RA. Vascular endothelial growth factor (VEGF) is the most important pro-angiogenic factor implicated in the pathogenesis of both RA and atherosclerosis. Therefore, this study aimed to determine the role of the VEGF -2578 polymorphism (rs699947) in changes in lipid profiles in Kurdish patients with RA. Methods: In this cross-sectional study, conducted in 2020, 130 patients with a confirmed diagnosis of rheumatoid arthritis who were referred to the Rheumatology Clinic of Tohid Hospital in Sanandaj were enrolled. Pain severity was assessed using the Visual Analog Scale (VAS). Plasma lipid profiles, including triglycerides (TG), total cholesterol (TC), and HDL-cholesterol, were measured by an auto-analyzer. Erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and rheumatoid factor (RF) values were recorded, and the severity of disease was calculated according to disease activity score-28 (DAS28) criteria. VEGF-2578 polymorphism was also genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: The genotype distributions of AA, AC, and CC and allele frequencies for the VEGF-2578 at rs699947 did not show any significant difference from the expected value of the Hardy-Weinberg equilibrium. The frequencies of AA, AC, and CC genotypes were 42.3%, 43.8%, and 13.8%, respectively. The VEGF-2578 CC genotype was shown to be inversely associated with atherogenic index (P = 0.01) and total cholesterol levels (P = 0.01). No significant relationship was found between the VEGF-2578 polymorphism and other lipid parameters, CRP, RF, and disease severity (P > 0.05). Conclusions: Our findings indicate that genetic variation in the VEGF gene is associated with plasma lipid profiles, including total cholesterol levels and the atherogenic index, in patients with RA, and may have implications for RA-related complications via its relationship with lipid metabolism.
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| Keywords: Rheumatoid arthritis, VEGF polymorphism, Atherosclerosis, Genetic polymorphism |
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Type of Study: Original Research |
Subject:
Molecular Medicine and Genetics
Received: 2020/08/5 | Accepted: 2026/06/14
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