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Postbiotics as a Safe Alternative to Live Probiotic Bacteria in the Food and Pharmaceutical Industries
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Aziz Homayouni Rad1    , Leili Aghebati Maleki2 , Hossein Samadi Kafil3 , Amin Abbasi 4, Nader Khani5 |
1- Department of Food Science and Technology, Faculty of Nutrition & Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
2- Immunology Research Center, Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
3- Drug Applied Research Center, Department of Microbiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
4- Student Research Committee, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran. , aminabasi.tbz.med.ac@gmail.com
5- Department of Food Science and Technology, Faculty of Nutrition & Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran |
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Abstract: (3090 Views) |
Background and Aim: Food is the fundamental need of human life and has nutrients that support growth and be healthy. Gastrointestinal tract (GI) microbiota involves beneficial microorganisms that develop therapeutic effects and are characterize as probiotics. The studies on appropriate probiotic strains have led to the separation and description of specific metabolic byproducts of probiotics named postbiotics.
Materials and Methods: A literature review has been performing using PubMed, Medline, and Scopus databases using combinations of search terms “probiotic, postbiotic, immune system, bioactivity, cancer, health-promoting, food, and pharmaceutical industry”. All experimental studies were enrolling for this explanatory review. Articles that did not have a full text were excluded.
Results: The probiotics must maintain their survival against inappropriate growth conditions of the processing, storage, distribution, preparation, and digestion system so that they can play their most health effects. Conversely, probiotic metabolites have successfully overcome these unfavorable conditions and maybe a good alternative to probiotics. Due to their specific chemical structure, safe profile, long shelf-life, and the fact that they contain various signaling molecules, postbiotics may have anti-inflammatory, immunomodulatory, antihypertensive, inhibiting abnormal cell proliferation, and antioxidant activities.
Conclusions: Postbiotics is mimic the fundamental and clinical role of probiotics, and due to their unique characteristics, can be applied in a delivery system (pharmaceutical/functional foods) to achieve health-promoting, prevention, and treatment purposes. |
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| Keywords: Postbiotic, Probiotic, Functional foods, Immune system, Health-promotion |
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Full-Text [PDF 995 kb]
(1331 Downloads)
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Type of Study: Original Research |
Subject:
General
Received: 2019/08/26 | Accepted: 2021/04/10 | Published: 2021/09/28
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Homayouni Rad A, Aghebati Maleki L, Samadi Kafil H, Abbasi A, Khani N. Postbiotics as a Safe Alternative to Live Probiotic Bacteria in the Food and Pharmaceutical Industries. SJKU 2021; 26 (4) :132-157 URL: http://sjku.muk.ac.ir/article-1-5312-en.html
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