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:: Volume 24, Issue 3 (Scientific Journal of Kurdistan University of Medical Sciences 2019) ::
SJKU 2019, 24(3): 96-109 Back to browse issues page
Change in total anti-oxidant capacity (TAC) of tissue, a new method for improving dermal wound healing
Majid Banimohammad1, Hooman Ravaei1, Parsa Khalafi2, Gholamali Javdan Dr3, Seyed Abdolmajid Ayatollahi4 , Seyed Hossein Davoodi 5
1- Physiology Research Center, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
2- School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
3- Minimally Invasive Surgery Research Center, Iran University of Medical Sciences, Tehran, Iran.
4- Phytochemical Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
5- Department of Basic Sciences and Cellular and Molecular Nutrition, Faculty of Nutrition Sciences and Food Technology and National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran , h.davoodi_18@yahoo.com
Abstract:   (241 Views)
in determining the physiological or physio-pathological function of oxygen reactive spices. Release of reactive oxygen species (ROS) in dermal wounds, leads to necrosis as well as apoptosis and tissue loss. Management of the risk factors for tissue loss due to flap failure can reduce risk factors with resultant improvement in the survival and efficacy of the flaps.
Materials and Methods: 40 Sprauge-Dawkey rats were divided into 4 groups (1) sham group with an 8×3 cm skin cut without skin elevation (2) Flap group with an 8×3 cm skin cut with skin elevation (3) cymophenol group treated with cymophenol (25 mg/kg/day) (4) cymophenol group treated with cymophenol (50 mg/kg/day) after surgery. After one week, percentage of the living tissue, superoxide dismutase (SOD) activity and amount of malondialdehyde (MDA) were measured in the groups and the proximity results were extracted. Using GraphPad Prism 6 software, data were analyzed and compared by ANOVA and Tukey test.
Results: Cymophenol application decreased the amount of malondialdehyde (p<0.05), increased superoxide dismutase activity (p<0.01), led to reduced oxidative stress in the flap tissues and increased resistance capacity against oxidative stress. Also we found improved survival rate of the flaps (p<0.05).
Conclusion: This study revealed the protective effect of cymophenol against oxidative stress and on survival of the flaps. However, more studies are required to determine its benefits in clinical use.
Keywords: Total antioxidant capacity, Wound healing, Oxidative stress, Cymophenol
Full-Text [PDF 591 kb]   (74 Downloads)    
Type of Study: Research | Subject: General
Received: 2018/11/4 | Accepted: 2019/07/7
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Banimohammad M, Ravaei H, Khalafi P, Javdan G, Ayatollahi S A, Davoodi S H. Change in total anti-oxidant capacity (TAC) of tissue, a new method for improving dermal wound healing. SJKU. 2019; 24 (3) :96-109
URL: http://sjku.muk.ac.ir/article-1-4518-en.html


Volume 24, Issue 3 (Scientific Journal of Kurdistan University of Medical Sciences 2019) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
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