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:: Volume 21, Number 1 (Scientific Journal of Kurdistan University of Medical Sciences 2016) ::
SJKU 2016, 21(1): 30-39 Back to browse issues page
Investigation of the effect of alcoholic Morus alba leave extract on scopolamine-induced spatial memory impairment in rats
Omid Reza Tamtaji, Mojgan Mohammadifar, Mohammad Behnam, Dr Mohsen Taghizadeh1, Seyed Alireza Talaei 2
1- Associate Professor
2- , talaei@kaums.ac.ir
Abstract:  

Background and Aim: Many learning and memory abilities decline in several diseases such as Alzheimer's and dementia. The present study investigated the effects of alcoholic extract of Morus alba leaves on scopolamine-induced spatial memory impairment in rats.

Material and Methods: In this experimental study, forty male Wistar rats were divided into 5 groups (n=8): control group, scopolamine control group, and groups receiving scopolamine plus alcoholic extract of Morus Alba leaves at doses of 100, 200 and 400 mg/kg/day. After 28 days, learning and spatial memory was evaluated by the Morris water maze. Statistical analysis was performed by repeated measures ANOVA and Bonferroni test.

Results: In scopolamine control group, the injection of scopolamine caused learning (P<0.0001) and spatial memory (P<0.05) impairment compared to the control group. Administration of alcoholic extract of Morus alba leaves at the doses of 100 (P<0.05), 200 (P<0.0001), and 400 mg/kg (P<0.0001) improved learning ability in rats. Also, these extracts at doses of 200 and 400 mg/kg prevented impairment of spatial memory in rats (P<0.05).

Conclusion: According to the results of this study an alcoholic extract of Morus alba leaves can enhance learning and memory function in rats receiving scopolamine.

Keywords: Morus alba, Scopolamine, Spatial memory, Learning; Morris water maze.

 

Received: Jun 19, 2015      Accepted: Jan 04, 2016

Keywords: Morus alba, Scopolamine, Spatial memory, Learning, Morris water maze.
Full-Text [PDF 1416 kb]      
Type of Study: Research | Subject: General
Received: 2016/03/11 | Accepted: 2016/03/11 | Published: 2016/03/11
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Volume 21, Number 1 (Scientific Journal of Kurdistan University of Medical Sciences 2016) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
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