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:: Volume 20, Number 6 (Scientifis Journal of Kurdistan University of Medical Sciences 2016) ::
SJKU 2016, 20(6): 69-75 Back to browse issues page
Association between rs763780 polymorphism in IL-17 gene and chronic hepatitis B infection in the patients referring to Taleghani Hospital, in Tehran, Iran
Hamideh Tayefinasrabadi 1, Dr Seyed Masood Hosseini2, Dr Seyed Reza Mohebbi3, Pedram Azimzadeh, Dr Mohammad Reza Zali4
1-
2- Associate Professor
3- Assistant Professor
4- Professor
Abstract:  

Background and Aim: Viral hepatitis B is one of the most prevalent infectious diseases which can lead to liver cirrhosis (LC) and hepatocellular carcinomas (HCC). Recent studies have shown an association between single nucleotide polymorphism (SNP) of interleukin 17 and inflammatory diseases. Inflammatory responses are important factors in the disease process, especially in the viral infections and chronicity or virus clearance from the body, and are closely dependent on the proper cytokine secretion from immune cells. The aim of this study was to investigate the association between IL-17 (rs763780) SNP and chronic Hepatitis B virus (HBV) Infection.

Material and Methods: Blood samples were collected from 150 patients with chronic HBV infection and 150 healthy individuals. Genomic DNA was extracted by salting out method. IL-17 (rs763780) polymorphism was determined by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) methods.

Results: Genotype and allele frequencies of rs763780 did not show any statistically significant difference between the patients and control groups.  Genotype frequencies were 84.6% for TT, 14.7% for TC and 0.7% for CC in the patients with chronic disease and 88%, 11.3% and 0.7% for TT, TC and CC in the control group respectively (p=0.69).

Conclusion: The results showed that there was no association between IL-17 SNP rs763780 and susceptibility to develop chronic HBV infection. It seems that genetic variations in other cytokine genes other than IL-17 gene, may affect progression of infection to chronic disease.

Keywords: Hepatitis B virus, Interleukin17, Single nucleotide polymorphism.

 

Received: Aug 16, 2015      Accepted: Nov 03, 2015

Keywords: Hepatitis B virus, Interleukin17, Single nucleotide polymorphism
Full-Text [PDF 223 kb]      
Type of Study: Research | Subject: General
Received: 2016/02/8 | Accepted: 2016/02/8 | Published: 2016/02/8
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Volume 20, Number 6 (Scientifis Journal of Kurdistan University of Medical Sciences 2016) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
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