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Evaluation of the relationship between cardiac risk factors and reduction of hypertension with sublingual captopril
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Hashem Kazerani   |
| Kermanshah University of Medical Sciences , hashemkazerani@kums.ac.ir |
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Abstract: (11272 Views) |
| ABSTRACT
Background and Aim: HTN is one of the main causes of cardiovascular diseases and its prevalence rate in adults is about 20-30 percent. In this study we evaluated the effects of age, gender, diabetes, cigarette smoking and hyperlipidemia on blood pressure after using 25 mg sublingual captopril.
Materials and methods: This randomized clinical trial was performed between 1383 and 1385 and included 101 patients with BP equal to or more than 180/110 mmHg. Patients with symptoms of acute ischemia or heart attack, CHF, CNS and visual disturbances, pregnancy or captopril sensitivity were excluded from the study. After prescribing 25 mg sublingual captopril, systolic and diastolic BP was measured after 5, 10, 15, 20, 25, 30, 40, 50, 60, 75, 90, 105 and 120 minutes. Data were recorded in a questionnaire for every patient. Data analysis was performed by using SPSS software and independent t-test.
Results: This study included 101 patients (34 men and 67 women), 42 patients were less than 60 year old and 59 patients were of 60 years of age and over. 14 patients were diabetic and 87 non diabetic, 20 were smoker and 81 non-smokers, 27 had hyperlipidemia and 74 were without hyperlipidemia. BP decreased between 5 and 25 percent in 70% of the patients (P =0.001).
There was no significant statistical relationship between decrease in blood pressure and age, gender and cigarette smoking. But non diabetic patients showed more reduction of BP in comparison to diabetic patients (P=0.014).
Non-hyperlipidemic patients showed better response to the treatment and a significant difference was observed after 60 minutes.
Conclusion: The results of this study showed that cardiac risk factors such as diabetes, smoking and hyperlipidemia may cause some alterations in endothelial function which can lead to decreased response to the treatment. We recommend more studies on this subject in the future, for further evaluation.
Key Word: Captopril, Hypertension, Risk factor, Kermanshah
Received: Apr 27, 2011 Accepted: Aug 25, 2012 |
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| Keywords: Captopril, Hypertension, Risk factor, Kermanshah |
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Full-Text [PDF 385 kb]
(3968 Downloads)
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Type of Study: Original Research |
Subject:
General
Received: 2012/12/11 | Published: 2012/12/15
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