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Effect of Hydroalcoholic Extract of Cinnamomum Zeylanicum on Apoptosis in the Right Prefrontal Cortex and Hippocampus of Male Rats in an Animal Model of Depression.
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Mohamad Raman Moloudi1    , Esmael Izadpanah2 , Fardin Fathi3 , Maryam Hoseinian4 |
1- Associate Professor of Physiology, Neurosciences Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran. , x.moloudi@gmail.com
2- Professor of Physiology, Cellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran
3- Professor of Anatomy, Neurosciences Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.
4- MSc of Anatomy, Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran, Kurdistan University of Medical Sciences, Sanandaj, Iran |
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Abstract: (220 Views) |
Background and Aim: Depression is one of the most common stress-related mood disorders. Cinnamon, a widely used food spice, possesses various medicinal properties, including antioxidant, sedative, mood-enhancing and neuroprotective effects. In this study, the effects of cinnamon hydroalcoholic extract on apoptosis in the prefrontal cortex and hippocampus were investigated using an animal model of depression.
Materials and Methods: Forty male Wistar rats (250 ± 25 g) were randomly divided into five groups: sham (receiving saline and DMSO. ip for 28 days), control (receiving saline and DMSO. ip for 28 days simultaneously with the depression induction protocol), positive control (receiving imipramine, 15 mg/kg, ip for 28 days simultaneously with the depression induction protocol), and two treatment groups (receiving cinnamon hydroalcoholic extract at concentrations of 200 and 400 mg/kg, ip for 28 days simultaneously with the depression induction protocol). On days 0, 7, 14, and 28, the animals were subjected to forced swimming and sucrose preference tests. On day 29, after anesthesia induction, the right prefrontal cortex and hippocampus were isolated to examine apoptosis. Behavioral and apoptosis data were analyzed using one-way ANOVA.
Results: The cinnamon hydroalcoholic extract (200 and 400 mg/kg) and imipramine (15 mg/kg) improved depression-induced behavioral symptoms by altering the indices of the forced swimming test compared to the control group. Furthermore, the cinnamon extract at 400 mg/kg significantly increased sucrose preference and decreased the percentage of TUNEL-positive cells in the right prefrontal cortex (P<0.05).
Conclusion: The hydroalcoholic extract of cinnamon, particularly at the 400 mg/kg dose, showed antidepressant-like and neuroprotective effects with behavioral consequences and reduced neuronal apoptosis in the right prefrontal cortex, indicating its potential as a promising complementary agent for the management of depressive disorder.
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| Keywords: Cinnamomum Zeylanicum, Forced swim test, Sucrose test, Depression, Apoptosis. |
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Full-Text [PDF 878 kb]
(55 Downloads)
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Type of Study: Original Research |
Subject:
Physiology and neurosciences
Received: 2025/09/28 | Accepted: 2025/11/26 | Published: 2026/04/11
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