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Ameliorative effect of Borago officinalis L extract on sperm parameters, testosterone level in a streptozotocin-induced mouse model of diabetes
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Nabaz Abasi1    , Shiva Khalesro2 , Erfan Daneshi3 |
1- Msc , Department of Plant Production and Genetics, Faculty of Agriculture, University of Kurdistan, Sanandaj, Iran & Msc , Department of Plant Production and Genetics, Faculty of Agriculture, University of Kurdistan, Sanandaj, Iran
2- Associate professor, Department of Plant Production and Genetics, Faculty of Agriculture, University of Kurdistan Sanandaj, Iran & Associate professor, Department of Plant Production and Genetics, Faculty of Agriculture, University of Kurdistan Sanandaj, Iran
3- Associate professor, Cellular and Molecular Research Center Department of Anatomy, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran & Associate professor, Cellular and Molecular Research Center Department of Anatomy, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran , erfan.daneshi@yahoo.com |
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Abstract: (1028 Views) |
Background and Aim: Diabetes mellitus (DM) is a common metabolic disease characterized by high blood sugar levels. It is well known that men with diabetes frequently experience reproductive disorders and sexual dysfunction. In fact, sperm quality has a significant impact on fertilization success and embryo development. The current study aimed to investigate the effect of Borago officinalis L extract on serum testosterone levels, sperm parameters, in the streptozotocin (STZ)-induced mouse model of diabetes.
Materials and Methods: In this research, 30 male mice were randomly divided in 3 groups control, diabetic (Streptozotocin 150 mg/kg) and diabetic + Borago officinalis L (400 mg/kg) groups. After 6 weeks of treatment, the mice were sacrificed and in each group of mice, sperm parameters and testosterone were measured
Results: The results revealed a decrease in body and testis weight and elevated blood FBS levels in the diabetic group, compared to the control. However, Borago treatment significantly increased body and testis weight, while serum FBS levels were decreased, in comparison to the diabetic group. In addition, Borago significantly increased blood testosterone levels, compared to the diabetic group.
Conclusion: The present study showed that, Borago officinalis in male mice has a healing effect on sperm parameters against the damage of diabetes
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| Keywords: Diabet, Streptozotocin, Borago officinalis L, sperm parameters |
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Full-Text [PDF 578 kb]
(313 Downloads)
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Type of Study: Original Research |
Subject:
Biology of Reproduction
Received: 2023/10/23 | Accepted: 2024/01/9 | Published: 2024/12/29
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abasi N, khalesro S, daneshi E. Ameliorative effect of Borago officinalis L extract on sperm parameters, testosterone level in a streptozotocin-induced mouse model of diabetes. SJKU 2024; 29 (5) :1-11 URL: http://sjku.muk.ac.ir/article-1-8161-en.html
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