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:: Volume 30, Issue 1 (Scientific Journal of Kurdistan University of Medical Sciences 2025) ::
SJKU 2025, 30(1): 69-81 Back to browse issues page
Impact of pediatric Bacillus Calmette Gurin vaccination on clinical outcomes of COVID-19 in adult hospitalized patients
Behzad Bijani1 , Amirhosein Samimifar2 , Abbas Allami3
1- Associate professor, Dept. of Infectious Diseases, Clinical Research Development Unit, BuAliSina Hospital, Qazvin University of Medical Sciences, Qazvin, Iran
2- Resident, Dept. of Infectious Diseases, Clinical Research Development Unit, BuAliSina Hospital, Qazvin University of Medical Sciences, Qazvin, Iran
3- Professor, Dept. of Infectious Diseases, Clinical Research Development Unit, BuAliSina Hospital, Qazvin University of Medical Sciences, Qazvin, Iran , allami9@yahoo.com
Abstract:   (719 Views)
Background and Aim The role of BCG vaccination in childhood on the outcomes of Covid-19 infection is still unclear. This study aimed to examine the association between BCG vaccination status and the severity, ICU admission, and mortality of Covid-19 pneumonia patients.
Materials and Methods This was a cross-sectional study of Covid-19 pneumonia patients admitted to Bo Ali Sinai Medical Education Center in Qazvin, Iran, from April 2022 to January 2023. Data on demographic characteristics, comorbidities, BCG vaccination status, and in-hospital outcomes, including severity of illness, ICU admission, and mortality, were collected and analyzed.
Results Of 203 patients (mean age 56 years, 43.8% male), 52.7% had a history of BCG vaccination. Logistic regression analysis showed that the number of comorbidities, lymphocyte percentage, and oxygen saturation at admission were inversely associated with ICU admission (odds ratio [OR] = 1.6, 0.9, and 0.8, respectively). Age and respiratory rate were positively associated with mortality (OR=1.2, 1.5). BCG vaccination and respiratory rate were positively associated with severity of Covid-19 (OR=8.5, 4.8), while oxygen saturation was negatively associated with severity of Covid-19 (OR=0.009). BCG vaccination status did not have a significant effect on ICU admission and mortality.
Conclusions This study did not find evidence that BCG vaccination in childhood alters the prognosis of Covid-19 pneumonia. Age and respiratory rate were the main predictors of in-hospital mortality in Covid-19 pneumonia patients.
 
Keywords: BCG Vaccine, SARS Coronavirus 2, comorbid, severity
Full-Text [PDF 728 kb]   (190 Downloads)    
Type of Study: Original Research | Subject: Medicine - Infectious
Received: 2023/07/30 | Accepted: 2024/02/6 | Published: 2025/03/12
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Bijani B, Samimifar A, Allami A. Impact of pediatric Bacillus Calmette Gurin vaccination on clinical outcomes of COVID-19 in adult hospitalized patients. SJKU 2025; 30 (1) :69-81
URL: http://sjku.muk.ac.ir/article-1-8022-en.html


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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 30, Issue 1 (Scientific Journal of Kurdistan University of Medical Sciences 2025) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
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