1- Ph.D. Student of Neuroscience, Department of Neuroscience and Addiction Studies, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran & Ph.D. Student of Neuroscience, Department of Neuroscience and Addiction Studies, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran 2- Student Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran & Student Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran 3- Ph.D. Student of Bacteriology, Department of Microbiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran & Ph.D. Student of Bacteriology, Department of Microbiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran 4- Ph.D. Student of Bacteriology, Department of Microbiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran & Ph.D. Student of Bacteriology, Department of Microbiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran , microbiology90@gmail.com 5- Bachelor of Biology, Department of Biology, Faculty of Basic Sciences, Payame Noor University of Pardis Branch, Tehran, Iran & Bachelor of Biology, Department of Biology, Faculty of Basic Sciences, Payame Noor University of Pardis Branch, Tehran, Iran
Abstract: (1470 Views)
Background and Aim: The gut microbiota, which is now recognized as an important organ of the human body, can have an impact on various neurological outcomes such as cogBackground and Aim: The gut microbiota, which is now recognized as an important organ of the human body, can have an impact on various neurological outcomes such as cognition, learning, and memory. The aim of this study was to investigate the relationship between gut microbiota and Parkinson's disease and also to highlight appropriate microbiota-based therapeutic approaches for Parkinson's disease Materials and Methods: In this study, we searched and extracted the articles based on the keywords of "Parkinson's", "gut microbiota", "gut microbiome", "fecal microbiota", "fecal microbiome", "probiotic", and "gut-brain axis" from all data bases. Our inclusion criteria included English and Persian language articles, original articles and articles with open access, and the exclusion criteria of the study included articles other than English and Persian articles, articles without open access, meta-analysis and review articles.Finally, 38 articles were reviewed and analyzed. Results: Fecal microbiota transplant and probiotics laid the groundwork for identifying the mechanisms underlying the ability of the gut microbiota to influence a host's brain and behavior. It could help in prevention or early diagnosis of Parkinson's disease possibly through some peripheral biomarkers. Conclusion: Recent studies have also shown that patients with Parkinson's disease have a disruption in gut microbiota balance (dysbiosis), but its exact role in causing the neurological disorder is still unknown. However, new approaches based on gut microbiota can be developed to prevent and treat neurological disorders such as Parkinson's disease.
Type of Study: Review |
Subject: Microbiology Received: 2023/06/30 | Accepted: 2023/11/7 | Published: 2024/09/18
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Kardan R, Nazari M, Hemmati J, Ahmadi A, Ashab M. A Novel Therapeutic Strategy for Parkinson's Disease based on the Gut Microbiota: A Rreview Article. SJKU 2024; 29 (3) :127-138 URL: http://sjku.muk.ac.ir/article-1-7974-en.html