|
A review on phytogenic compounds inhibit coronaviruses associated with respiratory syndrome in human
|
Majid Gholami-Ahangaran1    , Maryam Karimi-Dehkordi2 |
1- Associate Professor, Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran
2- Associate Professor, Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran , ma_karimivet58@yahoo.com |
|
|
Abstract: (1002 Views) |
Background and aim: So far, no significant success has been achieved in the specific treatment of coronavirus infections. Considering that herbal medicines have beneficial effects, using herbal compounds in mild coronavirus infections can be effective. The purpose of this study is to review recent studies on the effectiveness of herbal medicines in inhibiting human coronaviruses and to increase awareness for using herbal compounds as supportive medicines in reducing the severity of coronavirus infections.
Materials and methods: PubMed databases were used to search for articles containing the terms coronavirus, SARS (Severe Acute Respiratory Syndrome), and MERS (Middle East Respiratory Syndrome), as well as human and herbal medicine. The inclusion criteria were all full articles with the above-mentioned keywords and the exclusion criteria were summary articles and articles presented in conferences. A total of 35 articles on human coronaviruses were found. Most of the studies were about Covid-19 with 17 articles (48.57%). Eight articles (23.85%) were found on SARS and only one article (2.85%) on MERS. Nine articles (25.71%) on other human coronaviruses were searched and used.
Results: Some of the key compounds showing promising effects for the treatment of coronavirus in humans include scutellarein, silvestrol, tryptanthrin, psychosaponin B2, and lectins such as griffithsin, lycorine, and polyphenolics including quercetin, myristicin, caffeic acid, and isobavachalcone. The conducting clinical trials on humans, in vitro and in vivo tests are required to determine the level of safety, as well as to determine the therapeutic level for each compound.
Conclusion: Although some herbal compounds were considered for treatment in coronavirus; initial studies can focus on compounds that are already approved for medicinal use. It is hoped that using the information provided in this study, researchers will use the derivatives of natural compounds in the process of producing safe and effective anti-coronavirus therapeutic agents.
|
|
| Keywords: Coronavirus, COVID-19, Herbal Medicine, Human, Middle East Respiratory Syndrome, SARS-CoV-2 |
|
|
Full-Text [PDF 572 kb]
(240 Downloads)
|
Type of Study: Review |
Subject:
Microbiology
Received: 2023/05/2 | Accepted: 2024/03/17 | Published: 2024/12/29
|
|
|
|
|
|
|
| References |
1. De Haan CA, Vennema H, Rottier PJ. Assembly of the coronavirus envelope: homotypic interactions between the M proteins. Virol J. 2000; 74(11): 4967-78. [ DOI:10.1128/JVI.74.11.4967-4978.2000] [ PMID] [ ] 2. Ye Z-W, Yuan S, Yuen K-S, Fung S-Y, Chan C-P, Jin D-Y. Zoonotic origins of human coronaviruses. Int J Biol Sci 2020; 16(10): 1686. [ DOI:10.7150/ijbs.45472] [ PMID] [ ] 3. Gholami-Ahangaran MC, Saeed, Shoushtari A, Bozorgmehrifard MH, Eshratabadi F. Molecular identification and determination of infectious bronchitis virus type in cases of respiratory syndrome of broilers in Isfahan province. Iran J Vet Sci. 2008; 5(476-69. 4. Gholami-Ahangaran M, Sandra Mani J, Johnson J, Naiker M, Ahmadi-Dastgerdi A. Approaches to the use of herbal antiviral compounds against Covid 19 using therapeutic experiences in coronavirus infections of animals. Iran J Physiol Pharmacol. 2021; 5(62-77. 5. Chen B, Tian E-K, He B, Tian L, Han R, Wang S, et al. Overview of lethal human coronaviruses. Signal Transduct Target Ther 2020; 5(1): 1-16. [ DOI:10.1038/s41392-020-0190-2] [ PMID] [ ] 6. Kim HY, Eo EY, Park H, Kim YC, Park S, Shin HJ, et al. Medicinal herbal extracts of Sophorae radix, Acanthopanacis cortex, Sanguisorbae radix and Torilis fructus inhibit coronavirus replication in vitro. Antivir. Ther. 2010; 15 (5): 697-709. doi:10.3851/IMP1615 [ DOI:10.3851/IMP1615] [ PMID] 7. Gholami‐Ahangaran M, Karimi‐Dehkordi M, Akbari Javar A, Haj Salehi M, Ostadpoor M. A systematic review on the effect of Ginger (Zingiber officinale) on improvement of biological and fertility indices of sperm in laboratory animals, poultry and humans. Vet Med Sci. 2021; 7(5):1959-69. [ DOI:10.1002/vms3.538] [ PMID] [ ] 8. Wu CY, Jan JT, Ma SH, Kuo CJ, Juan HF, Cheng YSE, et al. Small molecules targeting severe acute respiratory syndrome human coronavirus. Proc. Natl. Acad. Sci. USA. 2004; 101 (27): 10012-10017. doi:10.1073/pnas.0403596101 [ DOI:10.1073/pnas.0403596101] [ PMID] [ ] 9. Cinatl J, Morgenstern Bو Bauer G, Chandra P, Rabenau H, Doerr HW. Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus. Lancet 361 (9374), 2003; 2045-2046. doi:10.1016/S0140-6736(03)13615-X [ DOI:10.1016/S0140-6736(03)13615-X] [ PMID] 10. Ho TY, Wu SL, Chen JC, Li CC, Hsiang CY. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 interaction. Antiviral Res. 2007; 74 (2): 92-101. doi:10.1016/j.antiviral.2006.04.014 [ DOI:10.1016/j.antiviral.2006.04.014] [ PMID] [ ] 11. Wang SQ, Du QS, Zhao K, Li AX, Wei DQ, Chou KC. Virtual screening for finding natural inhibitor against cathepsin-L for SARS therapy. Amino Acids. 2007; 33 (1): 129-135. doi:10.1007/s00726-006-0403-1 [ DOI:10.1007/s00726-006-0403-1] [ PMID] [ ] 12. Zhuang M, Jiang H, Suzuki Y, Li X, Xiao P, Tanaka T, et al. Procyanidins and butanol extract of Cinnamomi cortex inhibit SARS-CoV infection. Antiviral Res. 2009; 82 (1): 73-81. doi:10.1016/j.antiviral.2009.02.001. [ DOI:10.1016/j.antiviral.2009.02.001] [ PMID] [ ] 13. Lau KM, Lee KM, Koon CM, Cheung CSF, Lau CP, Ho HM, et al. Immunomodulatory and anti-SARS activities of Houttuynia cordata. J. Ethnopharmacol. 2008; 118 (1): 79-85. doi:10.1016/j.jep.2008.03.018 [ DOI:10.1016/j.jep.2008.03.018] [ PMID] [ ] 14. Toney JH, Navas-Martín S, Weiss SR, Koeller A. Sabadinine: a potential non-peptide anti-severe acute-respiratory-syndrome agent identified using structure-aided design. Journal of medicinal chemistry. 2004; 47(5): 1079-80. [ DOI:10.1021/jm034137m] [ PMID] 15. Lin CW, Tsai FJ, Tsai CH, Lai CC, Wan L, Ho TY. et al. Anti-SARS coronavirus 3C-like protease effects of Isatis indigotica root and plant-derived phenolic compounds. Antiviral Res. 2005; 67: 18-23. doi:10.1016/j.antiviral.2005.07.002 [ DOI:10.1016/j.antiviral.2005.07.002] [ PMID] [ ] 16. Lung J, Lin YS, Yang YH, Chou YL, Shu LH, Cheng YC, et al. The potential chemical structure of anti‐SARS‐CoV‐2 RNA‐dependent RNA polymerase. J Med Virol. 2020; 92(6): 693-7. [ DOI:10.1002/jmv.25761] [ PMID] [ ] 17. Hoever G, Baltina L, Michaelis M, Kondratenko R, Baltina L, Tolstikov GA, et al. Antiviral activity of glycyrrhizic acid derivatives against SARS− coronavirus. J Med Chem. 2005; 48(4): 1256-9. [ DOI:10.1021/jm0493008] [ PMID] 18. Loizzo MR, Saab AM, Tundis R, Statti GA, Menichini F, Lampronti I, et al. Phytochemical analysis and in vitro antiviral activities of the essential oils of seven Lebanon species. Chem Biodivers. 2008; 5(3): 461-70. [ DOI:10.1002/cbdv.200890045] [ PMID] [ ] 19. Wang G-F, Shi L-P, Ren Y-D, Liu Q-F, Liu H-F, Zhang R-J, et al. Anti-hepatitis B virus activity of chlorogenic acid, quinic acid and caffeic acid in vivo and in vitro. Antivir res. 2009; 83(2): 186-90. [ DOI:10.1016/j.antiviral.2009.05.002] [ PMID] 20. Kumaki Y, Wandersee MK, Smith AJ, Zhou Y, Simmons G, Nelson NM, et al. Inhibition of severe acute respiratory syndrome coronavirus replication in a lethal SARS-CoV BALB/c mouse model by stinging nettle lectin, Urtica dioica agglutinin. Antivir Res. 2011; 90(1): 22-32. [ DOI:10.1016/j.antiviral.2011.02.003] [ PMID] [ ] 21. Luo W, Su X, Gong S, Qin Y, Liu W, Li J, et al. Anti-SARS coronavirus 3C-like protease effects of Rheum palmatum L. extracts. Bioscience trends. 2009; 3(4). 22. Park J-Y, Kim JH, Kim YM, Jeong HJ, Kim DW, Park KH, et al. Tanshinones as selective and slow-binding inhibitors for SARS-CoV cysteine proteases. Bioorganic & medicinal chemistry. 2012; 20(19): 5928-35. [ DOI:10.1016/j.bmc.2012.07.038] [ PMID] [ ] 23. Park J-Y, Yuk HJ, Ryu HW, Lim SH, Kim KS, Park KH, et al. Evaluation of polyphenols from Broussonetia papyrifera as coronavirus protease inhibitors. Journal of enzyme inhibition and medicinal chemistry. 2017; 32(1): 504-12. [ DOI:10.1080/14756366.2016.1265519] [ PMID] [ ] 24. Millet JK, Séron K, Labitt RN, Danneels A, Palmer KE, Whittaker GR, et al. Middle East respiratory syndrome coronavirus infection is inhibited by griffithsin. Antiviral research. 2016; 133(1-8. [ DOI:10.1016/j.antiviral.2016.07.011] [ PMID] [ ] 25. Müller C, Schulte FW, Lange-Grünweller K, Obermann W, Madhugiri R, Pleschka S, et al. Broad-spectrum antiviral activity of the eIF4A inhibitor silvestrol against corona-and picornaviruses. Antiviral research. 2018; 150(123-9. [ DOI:10.1016/j.antiviral.2017.12.010] [ PMID] [ ] 26. Shen Y-C, Wang L-T, Khalil AT, Chiang LC, Cheng P-W, Bioactive pyranoxanthones from the roots of Calophyllum blancoi. Chemical and pharmaceutical bulletin. 2005; 53: 244-7. [ DOI:10.1248/cpb.53.244] [ PMID] 27. Cheng PW, Ng LT, Chiang LC, Lin CC, Antiviral effects of saikosaponins on human coronavirus 229E in vitro. Clinical and Experimental Pharmacology and Physiology. 2006; 33: 612- [ DOI:10.1111/j.1440-1681.2006.04415.x] [ PMID] [ ] 28. Michaelis M, Doerr HW, Cinatl Jr J, Investigation of the influence of EPs® 7630, a herbal drug preparation from Pelargonium sidoides, on replication of a broad panel of respiratory viruses. Phytomedicine. 2011; 18: 384-6. [ DOI:10.1016/j.phymed.2010.09.008] [ PMID] [ ] 29. Müller C, Schulte FW, Lange-Grünweller K, Obermann W, Madhugiri R, Pleschka S, et al., Broad-spectrum antiviral activity of the eIF4A inhibitor silvestrol against corona-and picornaviruses. Antiviral research. 018; 150: 123-9. [ DOI:10.1016/j.antiviral.2017.12.010] [ PMID] [ ] 30. Tsai Y-C, Lee C-L, Yen H-R, Chang Y-S, Lin Y-P, Huang S-H, et al., Antiviral action of tryptanthrin isolated from Strobilanthes cusia leaf against human coronavirus NL63. Biomolecules. 2020; 10: 366. [ DOI:10.3390/biom10030366] [ PMID] [ ] 31. Weng J-R, Lin C-S, Lai H-C, Lin Y-P, Wang C-Y, Tsai Y-C, et al., Antiviral activity of Sambucus FormosanaNakai ethanol extract and related phenolic acid constituents against human coronavirus NL63. Virus research. 2019; 273: 197767. [ DOI:10.1016/j.virusres.2019.197767] [ PMID] [ ] 32. O'Keefe BR, Giomarelli B, Barnard DL, Shenoy SR, Chan PK, McMahon JB, et al., Broad-spectrum in vitro activity and in vivo efficacy of the antiviral protein griffithsin against emerging viruses of the family Coronaviridae. Journal of virology. 2010; 84: 2511-21.
https://doi.org/10.1128/JVI.00537-10 [ DOI:10.1128/JVI.02322-09] [ PMID] [ ] 33. Kim DE, Min JS, Jang MS, Lee JY, Shin YS, Park CM, et al., Natural bis-benzylisoquinoline alkaloids-tetrandrine, fangchinoline, and cepharanthine, inhibit human coronavirus OC43 infection of MRC-5 human lung cells. Biomolecules. 2019; 9: 696. [ DOI:10.3390/biom9110696] [ PMID] [ ] 34. Lung J, Lin YS, Yang YH, Chou YL, Shu LH, Cheng YC, et al. The potential chemical structure of anti‐SARS‐CoV‐2 RNA‐dependent RNA polymerase. Journal of medical virology. 2020; 92(6): 693-7. [ DOI:10.1002/jmv.25761] [ PMID] [ ] 35. Toney JH, Navas-Martín S, Weiss SR, Koeller A. Sabadinine: a potential non-peptide anti-severe acute-respiratory-syndrome agent identified using structure-aided design. Journal of medicinal chemistry. 2004; 47(5): 1079-80. [ DOI:10.1021/jm034137m] [ PMID] 36. Li S-y, Chen C, Zhang H-q, Guo H-y, Wang H, Wang L, et al. Identification of natural compounds with antiviral activities against SARS-associated coronavirus. Antiviral research. 2005; 67(1): 18-23. [ DOI:10.1016/j.antiviral.2005.02.007] [ PMID] [ ] 37. Yu M-S, Lee J, Lee JM, Kim Y, Chin Y-W, Jee J-G, et al. Identification of myricetin and scutellarein as novel chemical inhibitors of the SARS coronavirus helicase, nsP13. Bioorganic & medicinal chemistry letters. 2012; 22(12): 4049-54. [ DOI:10.1016/j.bmcl.2012.04.081] [ PMID] [ ] 38. Miean KH, Mohamed S. Flavonoid (myricetin, quercetin, kaempferol, luteolin, and apigenin) content of edible tropical plants. Journal of agricultural and food chemistry. 2001; 49(6): 3106-12. [ DOI:10.1021/jf000892m] [ PMID] 39. Zhao Q, Chen X-Y, Martin C. Scutellaria baicalensis, the golden herb from the garden of Chinese medicinal plants. Science bulletin. 2016; 61(18): 1391-8. [ DOI:10.1007/s11434-016-1136-5] [ PMID] [ ] 40. Runfeng L, Yunlong H, Jicheng H, Weiqi P, Qinhai M, Yongxia S, et al. Lianhuaqingwen exerts anti-viral and anti-inflammatory activity against novel coronavirus (SARS-CoV-2). Pharmacological research. 2020; 156(104761. [ DOI:10.1016/j.phrs.2020.104761] [ PMID] [ ] |
|
| Send email to the article author |
|
|
|
| Add your comments about this article |
|
|
|
|
|
