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:: Scientific Journal of Kurdistan University of Medical Sciences- NO 5, 2023 -Articles In press ::
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Effects of L-serine on oxidative stress indices and histopathological changes of pancreas in streptozotocin-induced diabetic mice
Akram Vatannejad 1, Asma Kheirollahi
1- , vatannejad@ut.ac.ir
Abstract:   (35 Views)
Background and Aim: Diabetes mellitus is a metabolic disorder with an increasing global prevalence that can lead to premature death. High blood glucose is the main symptom of diabetes mellitus as a consequence of disorder in pancreatic insulin secretion or function. L-Serine supplementation regarded as safe by the FDA can improve glucose homeostasis, and reduce homeostasis model assessment-estimated insulin resistance (HOMA-IR) and oxidative stress. The aim of this study was to investigate the effects of L-serine intake on oxidative stress indices and histopathologic changes in the pancreas of diabetic mice.
Materials and Methods: In order to conduct this study, 18 c57bl/6 male mice were purchased and divided into 3 groups (control, diabetic control and diabetic mice treated by L-serine(. Diabetes induced by chemical method (streptozotocin, 200 mg/kg). After four weeks of oral administration of L-Serine (approximately 280 mg/day/mouse), animals were euthanized by guillotine and blood samples and pancreas tissues were used to determine biochemical parameters, oxidative stress indices and pathological changes.
Results: The results of this study showed that the oral administration of the supplement of L-Serine in diabetic mice could help to lower blood sugar levels and could lead to increased catalase enzyme activity (p<0.05) but had no significant effect on the level of MDA, cholesterol and triglyceride. On the other hand, histopathological changes showed a slight reduction in diabetes-induced pancreas damage in mice treated with L-serine.
Conclusions: These findings show that the supplement of L-Serine may has an effective influence on diabetes-induced pancreas damage by lowering blood sugar and improving oxidative stress status.
 
Keywords: Diabetes, L-Serine, pancreas, oxidative stress, histopathology, amino acid
     
Type of Study: Original Research | Subject: Biochemistry and Clinical Laboratory
Received: 2023/01/22 | Accepted: 2023/07/29
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Ethics code: IR.UT.VETMED.REC.1401.012


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مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
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