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Clinical Manifestations, Histopathological Findings, and Evaluation of Response to Treatment in Parathyroidectomy Specimens
in Hospitals of Babol City
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Novin Nikbakhsh1    , Fatemeh Amiri2 , Sekineh Kamali Ahangar3 , Sepideh Siadati4 , Mohammad Ranaee5 |
1- Professor of Thoracic, Clinical Research Development Unit of Shahid Beheshti Hospital, Babol University of Medical Sciences, Babol, Iran. & Professor of Thoracic, Clinical Research Development Unit of Shahid Beheshti Hospital, Babol University of Medical Sciences, Babol, Iran.
2- Student of General Medicine, Student Research Committee, Babol University of Medical Sciences, Babol, Iran. & Student of General Medicine, Student Research Committee, Babol University of Medical Sciences, Babol, Iran.
3- Midwifery Expert, Clinical Research Development Center, Shahid Beheshti Hospital, Babol University of Medical Sciences, Babol, Iran & Midwifery Expert, Clinical Research Development Center, Shahid Beheshti Hospital, Babol University of Medical Sciences, Babol, Iran
4- Associate Professor of Pathology, Cancer Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran & Associate Professor of Pathology, Cancer Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
5- Associate Professor of Pathology, Clinical Research Development Unit of Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran & Associate Professor of Pathology, Clinical Research Development Unit of Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran , drm.ranaee@yahoo.com |
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Abstract: (992 Views) |
Background and Aim: Primary hyperparathyroidism leads to increased secretion of parathyroid hormone and hypercalcemia. Parathyroid lesions are often in the form of adenoma, hyperplasia, and carcinoma. The aim of this study was to investigate clinical manifestations, pathological findings, and the response to the treatment in the patients with parathyroidectomy.
Materials and Methods: In this cross-sectional-analytical study (2002-2017),we extracted data from 37 records of the patients who had undergone parathyroidectomy in the hospitals associated with Babol University of Medical Sciences. The data were about age, gender, pre-and post-operative values of laboratory indices, pathology of the lesions, and the surgical procedure. Using SPSS- 20 software, data were analyzed by, descriptive statistics, Fisher's exact and Wilcoxon's statistical tests (P<0.05).
Results: The majority of patients were female (67.57 %) and the mean age was 47.13 ± 15.27 years. The disease with skeletal manifestations was more common (45.28%). Adenoma was the most common type of lesion in radiology (78.37 %) and pathology (63.41 %) and the predominant surgical method was unilateral exploration (64.86%). A statistically significant relationship was observed between the type of pathological lesion and the patient's age grou (p=0.037) and gender(p = 0.013). The success of parathyroidectomy surgery was evaluated as significant based on the pre- and post-operative values of calcium (P<0.001) and parathormone (P<0.001).
Conclusions: Primary hyperparathyroidism disease in Iran is a symptomatic disorder that most frequently manifests with bone symptoms, and parathyroidectomy surgery is the definitive treatment method. Improvement of bone symptoms, measurement of calcium, and parathormone can be considered indicators of improvement in these patients.
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| Keywords: Primary hyperparathyroidism, Parathyroidectomy, Hyperplasia, Parathyroid adenoma |
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Full-Text [PDF 604 kb]
(206 Downloads)
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Type of Study: Original Research |
Subject:
Medicine - General Surgery
Received: 2022/07/27 | Accepted: 2023/07/31 | Published: 2024/09/18
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Ethics code: MUBABOL.HRI.REC.1396.95
Nikbakhsh N, Amiri F, Kamali Ahangar S, Siadati S, Ranaee M. Clinical Manifestations, Histopathological Findings, and Evaluation of Response to Treatment in Parathyroidectomy Specimens
in Hospitals of Babol City. SJKU 2024; 29 (3) :38-50 URL: http://sjku.muk.ac.ir/article-1-7464-en.html
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