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Nanostructured drug delivery systems for targeted treatment of cancer
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Leila Barghi  |
| urmia university of medical sciences , leila.barghi@gmail.com |
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Abstract: (236 Views) |
Background and Aim: Nanostructured drug delivery systems have investigated as delivery systems for chemotherapeutic agents in cancer treatment recently.
Materials and Methods: Data of this review article were collected by searching PubMed and WOS (Web of Science) using the keywords of cancer, nanomedicin, nanoparticles, liposome and solubility.
Results: Among the various nanostructured drug delivery systems, liposomes, solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs), polymeric nanoparticles, micelles, albumin nanoparticles and drug – polymer conjugated used to develop the efficient delivery systems of chemotherapeutics for cancer treatment. Many chemotherapeutic drugs are highly hydrophobic with low aqueous solubility. Furthermore, non-specificity, toxicity and drug resistance are the main drawback of cancer treatment with chemotherapeutic drugs. Utilizing nanostructured delivery systems are the main approach to overcome drug resistance, reduce side effects and improve treatment efficacy. Additionally nanostructures containing two or more drugs for combination therapy of cancer are challenging issues that can increase the treatment efficiency of cancer.
Conclusion: Although the development of various nanostructured drug delivery systems for chemotherapeutics are under investigation, but few of these systems have passed clinical studies and entered the pharmaceutical market as approved nanomedicines.
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| Keywords: cancer, nanomedicin, nanoparticles, liposome, solubility |
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Type of Study: Review |
Subject:
Nano technology
Received: 2022/07/25 | Accepted: 2023/03/6
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