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Central Library of Kurdistan University of Medical Sciences
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:: Volume 28, Issue 4 (Scientific Journal of Kurdistan University of Medical Sciences 2023) ::
SJKU 2023, 28(4): 95-109 Back to browse issues page
Effect of Silymarin on Hepatic Complications Caused by Methotrexate and its Analgesic Effects in Patients with Rheumatoid Arthritis
Abbas Alimoradian1 , Masoume Garshasbi2 , Mohaddeseh Asafari3 , Mohammad Golitaleb4 , Reza Mansouri Tabar5 , Sepideh Mortaji khiabani6 , Reza Tajik 7
1- Department of Pharmacology, School of Medicine, Arak University of Medical Sciences, Arak, Iran.
2- Student Research Committee, Department of Nursing, School of Nursing, Arak University of Medical Sciences, Arak, Iran
3- Department of Food Safety and Hygiene, School of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4- School of Nursing, Arak University of Medical Sciences, Arak, Iran.
5- Arak University of Medical Sciences,Arak,Iran
6- Rheumatology, Arak University of Medical Sciences, Arak, Iran.
7- Department of Occupational Health Engineering, School of Public Health, Arak University of Medical Sciences, Arak, Iran , t.rezatajik@yahoo.com
Abstract:   (1250 Views)
Background and Aim: Methotrexate is an important drug for treatment of rheumatoid arthritis (RA) but is associated with adverse side effects on liver. In this study we evaluated the effect of silymarin on methotrexate induced hepatotoxicity and its analgesic effects in the patients taking this drug.
Materials and Methods: This study inclouded 58 patients with RA. Patients who had been treated with 2.5 mg methotrexate three times a week for six months were randomly divided into two groups of A and B. Group A received methotrexate and group B treated with 280 mg of silymarin tablets daily (two doses for 2 months) in addition to methotrexate. At baseline (before tests) and after two months, both groups completed the VAS (Visual Analogue Scale) questionnaire and Cr (Creatinine), BUN (Blood Urea Nitrogen), ESR (Erythrocyte Sedimentation Rate), Hemoglobin, WBC (white blood cell), PLT (Platelet) and the liver tests including ALT (Alanine Transaminase) and AST (Aspartate Aminotransferase) were evaluated. We used t-test for data analysis.
Results: In the group B, ALT, AST and ESR, Cr and BUN decreased significantly. Also clinical signs of pain which were indicative of pain intensity were decreased.
Conclusion: Use of silymarin in the patients with RA reduced liver enzymes, liver toxicity and renal complications, which may be due to its antioxidant and cell membrane stabilization properties.
 
Keywords: Methotrexate, Silymarin, Liver complications, Alanine transferase, Aspartate transferase
Full-Text [PDF 757 kb]   (286 Downloads)    
Type of Study: Original Research | Subject: Pharmacology
Received: 2021/12/25 | Accepted: 2022/07/6 | Published: 2023/09/27
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Ethics code: IR.ARAKMU.REC.1398.130
Clinical trials code: IRCT20180519039711N4

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Alimoradian A, Garshasbi M, Asafari M, Golitaleb M, Mansouri Tabar R, Mortaji khiabani S et al . Effect of Silymarin on Hepatic Complications Caused by Methotrexate and its Analgesic Effects in Patients with Rheumatoid Arthritis. SJKU 2023; 28 (4) :95-109
URL: http://sjku.muk.ac.ir/article-1-7159-en.html
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Volume 28, Issue 4 (Scientific Journal of Kurdistan University of Medical Sciences 2023) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
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