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:: Volume 13, Issue 1 (Scientific Journal of Kurdistan University of Medical Sciences 2008) ::
SJKU 2008, 13(1): 13-20 Back to browse issues page
Effect of gabapentin on opioid withdrawal symptoms in opium dependent patients
Gholamreza Kheirabadi 1, Mansour Ranjkesh , Mohammad Reza Maracy , Mehrdad Salehi
1- , kheirabadi@bsrc.mui.ac.ir
Abstract:   (86358 Views)
ABSTRACT Background and Aim: This randomized double-blind, placebo controlled study was performed to evaluate the effectiveness of gabapentin in the treatment of opiate withdrawal symptoms. Material and Methods: This was a 3-week double-blind, randomized, placebo-controlled trial and performed in specialized addiction behavior unit, an outpatient unit for the treatment of patients with addiction in Isfahan. The study included forty patients, 37 males and 3 females, between 21-61 years of age who met DSM-IV criteria for opium dependence. The subjects were randomly assigned into 2 groups. The experimental group received MAD (methadone-assisted detoxification) and gabapentin 900 mg/day. Severity of different withdrawal symptoms was measured by using subjective opiate withdrawal scale (SWOS) in six steps. Results: Despite superiority of gabapentin to placebo in controlling some of withdrawal symptoms no significant difference was noticed between the two groups. Conclusion: Addition of 900 mg/day of gabapentin to MAD treatment regimen is not significantly superior to placebo in controlling opium withdrawal symptoms. Key words: Gabapentin, Opium dependent, Withdrawal symptoms, Opioid
Keywords: Gabapentin, Opium dependent, Withdrawal symptoms, Opioid
Full-Text [PDF 140 kb]   (13049 Downloads)    
Type of Study: Original Research | Subject: General
Received: 2009/04/12 | Published: 2008/06/15
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Kheirabadi G, Ranjkesh M, Maracy M R, Salehi M. Effect of gabapentin on opioid withdrawal symptoms in opium dependent patients. SJKU 2008; 13 (1) :13-20
URL: http://sjku.muk.ac.ir/article-1-69-en.html


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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 13, Issue 1 (Scientific Journal of Kurdistan University of Medical Sciences 2008) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
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