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Comparison of Dexmedetomidine with Acetaminophen and Its Combination (Apodex) on Pain Control, Emergence Agitation and Delirium in Pediatric Patients Undergoing Adenotonsillectomy with Sevoflurane
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Farzad Sarshivi1    , Negin Ghadami2 , Karim Naseri3 , Soraya Sarshivi4 |
1- Kurdistan University of Medical Sciences, Sanandaj, Iran & Department of Anesthesiology, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran , sciences1398@gmail.com
2- Department of Anesthesiology, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran & Department of Anesthesiology, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran
3- Kurdistan University of Medical Sciences, Sanandaj, Iran & Department of Anesthesiology, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran
4- Kurdistan University of Medical Sciences, Sanandaj, Iran & Physician, Kurdistan University of Medical Sciences, Sanandaj, Iran |
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Abstract: (882 Views) |
Background and Aim: Adenotonsillectomy is one of the most common pediatric surgeries and is often associated with postoperative emergence agitation and pain. The aim of this study was to comparison of dexmedetomidine with acetaminophen and its combination (Apodex) on pain control, emergence agitation and delirium in pediatric patients undergoing adenotonsillectomy with sevoflurane.
Materials and Methods: In this randomized double-blind clinical trial, 132 patients, between 2 and 12 years, candidates for adenotonsillectomy were examined in four groups (n=33). In all groups induction of anesthesia were performed in a similar manner. In the first group, acetaminophen (15 mg/kg), in the second group, dexmedetomidine (1 µg/kg), in the third group, apodex, which is a combination of acetaminophen (10 mg/kg) and dexmedetomidine (0.3 g/kg) were prescribed. The fourth group received (50 ml) normal saline as a placebo intravenously within 15 minutes before the end of surgery. Version 12 of STATA software was used for data analysis.
Results: Acetaminophen, dexmedetomidine and apodex reduced pain, emergence agitation and delirium compared with the control group (P<0.05). It should be noted that dexmedetomidine and apodex had better effects compared with acetaminophen (P<0.05).
Conclusion: Acetaminophen, dexmedetomidine and apodex can be used to control pain, emergence agitation and delirium after adenotonsillectomy. Dexmedetomidine and apodex have better effects in controlling pain and emergence agitation.
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| Keywords: Acetaminophen, Dexmedetomidine, Apodex, Adenotonsillectomy, Sevoflurane |
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Full-Text [PDF 543 kb]
(175 Downloads)
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Type of Study: Original Research |
Subject:
Medicine - Anesthesia
Received: 2021/03/2 | Accepted: 2021/11/1 | Published: 2024/12/29
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Ethics code: 275/1395 IR.MUK.REC
sarshivi F, ghadami N, naseri K, sarshivi S. Comparison of Dexmedetomidine with Acetaminophen and Its Combination (Apodex) on Pain Control, Emergence Agitation and Delirium in Pediatric Patients Undergoing Adenotonsillectomy with Sevoflurane. SJKU 2024; 29 (5) :49-59 URL: http://sjku.muk.ac.ir/article-1-6625-en.html
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