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:: Scientific Journal of Kurdistan University of Medical Sciences- NO 4, 2022 ::
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Association of HOTAIR (rs920778 C>T) Polymorphism with Thyroid Cancer Susceptibility in Northwest of Iran
Majid Khalili Namarvar1 , Nasser Pouladi1 , Sara Ghaffarin 2
1- Azarbaijan Shahid Madani University
2- Azarbaijan Shahid Madani University , s.ghaffarian@azruniv.ac.ir
Abstract:   (132 Views)
ABSTRACT
Background and Aim: HOTAIR is a long noncoding RNA) that is transcribed from the antisense strand of the homeobox C gene and acts as an oncogene. This study was done to assess the association of HOTAIR (rs920778 C>T) gene polymorphism with the risk of thyroid cancer in northwest Iran.
Materials and Methods: In this case-control study, the association of HOTAIR (rs920778 C>T) gene polymorphism with thyroid cancer susceptibility in a statistical population consisting of 109 patients and 198 healthy controls was studied by PCR-PFLP. Statistical analysis was performed using javastat online statistics package and SPSS V.26.
Results: In the case group, the frequency of TT, CC, and TC genotypes were 46.78%, 29.35%, and 23.85%, respectively and they were 38.88%, 20.20%, and 40.90% for the control group. Statistical analysis showed a significant association between TC genotype (p-value=0.003) (OR=0.452, CI 95%=0.268-0.764) and thyroid cancer risk. Also, C and T allele frequency in case group, was 41.28% and 58.71% and them in the control group were 40.65% and 59.34% respectively. There was no significant relationship between T (p-value=0.088) and C (p-value=0.088) allele frequency and thyroid cancer risk in Northwestern Iran.
 Conclusion: These findings suggest rs920778 C>T polymorphism may contribute to thyroid cancer susceptibility in northwestern Iran. There was no significant association between rs920778C >T polymorphism and patient’s pathological traits consisting of age, tumor grade, lymph involvement, side involved, tumor size, tumor stage and type of thyroid tumor.
Keywords: Single Nucleotide Polymorphism, Thyroid cancer, HOTAIR gene, rs920778C>, T, PCR-PFLP
     
Type of Study: Original Research | Subject: Molecular Medicine and Genetics
Received: 2021/02/23 | Accepted: 2021/12/21
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Ethics code: IR.TBZMED.REC.1399.642


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مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
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