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Compression of the Analgesic Effect of Intravenous Metoclopramide and Ondansetron in combination with morphine in Renal Colic Patients
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Mohammadali Jafari nodoushan1  , Soheila Azimi abarghouei1 , Faeze Zeinali nasrabadi1 , Ali Raee ezzabadi1 , Naser Mohammad karimi1 , Mohammadreza Kazemi 2 |
1- Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2- Shahid Sadoughi University of Medical Sciences, Yazd, Iran , Kazemim360@gmail.com |
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Abstract: (321 Views) |
Background and Aim: The present study was aimed to compare the analgesic effects of ondansetron and metoclopramide in combination with morphine in relieving pain in patients with acute renal colic referred to the emergency department.
Materials and Methods: Patients were randomly divided into three groups A, B and C. In group A patients treated with 0.1 mg/kg intravenous morphine and 0.075 mg/kg ondansetron (maximum 4 mg), in group B patients treated with same dose of intravenous morphine and 0.15 mg/kg metoclopramide (maximum 10 mg) and in group C patients were treated with intravenous morphine at the same dose and 5 cc of normal saline. Pain intensity was assessed at the beginning of the study and 15, 30, 60 and 120 minutes after receiving the drug by Visual Analog Scale (VAS).
Results: In this study, 150 patients in three groups were included. The mean age of patients was 34.51 ± 7.84. There was no significant difference between the three groups in terms of gender distribution (p = 0.737) and mean age (p = 0.57). Results: The mean VAS score was not significantly different in the three groups at the beginning of the study (p=0.338). But at 15th minute VAS score in the metoclopramide and ondansetron groups was significantly less than the control group (p=0.044). At 30th minute, the difference in pain intensity between the three groups was again non-significant (p=0.164). But at 60th and 120th minute, the VAS score in the metoclopramide group was significantly less than the two other groups. (p=0.033 and p=0.009). Also, in the intragroup analysis, the VAS score was significantly reduced in all three groups during the study (p <0.001). Patient’s average length of stay in emergency department was 53±18 minutes in the metoclopramide group, 72±31 minutes in the ondansetron group and 80±31 minutes in the control group (p <0.001). In the metoclopramide group, 2 patients had extrapyramidal complications.
Conclusion: Our findings indicated that metoclopramide and ondansetron have analgesic effects in addition to nausea. The analgesic and antiemetic effect of metoclopramide and its effect on reducing the length of hospital stay is greater than ondansetron. |
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| Keywords: Pain - Metoclopzamide - Ondansetron - Renal colic |
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Type of Study: Original Research |
Subject:
Medicine - Emergency Medicine
Received: 2020/09/20 | Accepted: 2022/11/7
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