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Rapid and Progressive Transformation of Well-Differentiated Retroperitoneal Liposarcoma to Poorly Differentiated Type: A Case Report
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Mehdi Kardoust Parizi1    , Mohammad mehdi Miri2 |
1- Department of urology, School of medicine, Tehran university of medical sciences, Tehran, Iran , m.kardoust@yahoo.com
2- Department of urology, School of medicine, Tehran university of medical sciences, Tehran, Iran |
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Abstract: (2139 Views) |
Background and Aim: Retroperitoneal liposarcoma (LS) is a rare neoplasm. Well-differentiated LS is a slow-growing subtype with a high rate of recurrence. Despite the high recurrence rate after complete surgical resection, tumor transformation to poorly-differentiated LS is very rare.
Case: A 45-year-old man with a primary retroperitoneal tumor and the final pathology of well-differentiated LS underwent tumor resection surgery. Local recurrence was detected nine months after surgery. Second surgical resection revealed a poorly-differentiated subtype of LS which was treated with adjuvant radiation therapy. No local recurrence and distant metastasis were detected in a three years follow-up period.
Conclusion: Tumor transformation of well-differentiated retroperitoneal LS to poorly-differentiated subtype is extremely rare. Nevertheless, this rare case was successfully managed in a multi-disciplinary setting using surgical resection and adjuvant radiation therapy.
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| Keywords: Liposarcoma, Retroperitoneal Sarcoma, Retroperitoneal Tumor, Radiation Therapy. |
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Full-Text [PDF 246 kb]
(607 Downloads)
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Type of Study: case report |
Subject:
Medicine - Urology
Received: 2020/07/24 | Accepted: 2021/07/14 | Published: 2022/09/11
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