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:: Scientific Journal of Kurdistan University of Medical Sciences - No 2, 2022 ::
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The effect of Origanum vulgare on histological damage, oxidative stress and sperm parameters following induction of ischemia/reperfusion in adult testicular rat
Sajjad Abbasi , Sohrab Azin , Masoumeh Fani , Malihe Soltani , Hosein Abtahi-Eivary , Maryam Moghimian 1
1- , moghimian.m@gmu.ac.ir
Abstract:   (184 Views)
Background and Aim: The aim of this study was to investigate the effect of Origanum vulgare administration on testicular injury due to torsion/detorsion.
Materials and Methods: In this experimental study, 64 adult rats were divided into 8 equal groups. 1.Sham: the abdominal cavity was opened and then closed. 2.Torsion/detorsion (TD): Spermatic cord twisting for 4 hours and then opening the twist, 30 minutes before opening the normal saline injection twist. 3.Torsion/detorsion+ Origanum vulgare (TD+OV): Similar to group 2, with the difference that, it was injected in 3 separate groups of Origanum vulgare with different doses (400 mg/kg, 250, 100). 4. Origanum vulgare recipient (OV): Without any surgery, Origanum vulgare was injected in 3 separate groups with different doses (400 mg/kg, 250, 100). Twenty-four hours after surgery, a blood sample was taken to check for oxidative stress factors, and the testicular tissue was removed to check for histological changes, and the epididymis to measure sperm parameters. Finally, the data were analyzed using SPSS software.
Results: Histological examination data (Johnson's score, epithelium height, and seminiferous tubule diameter), sperm analysis (number and morphology) and, oxidative stress factors (MDA, SOD, GPx and, Catalase) in the TD group relative to the Sham group was significantly reduced (P= 0.0001) while in TD+OV groups it was improved compared to the TD group, but in most cases, the results were not significant.
Conclusion: It seems that Origanum vulgare can partially reduce the damage caused by testicular torsion/detorsion.
Keywords: torsion/detorsion, testis, Spermatozoa, Oxidative Stress, Origanum.
     
Type of Study: Original Research | Subject: Physiology and neurosciences
Received: 2020/07/2 | Accepted: 2021/06/13
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مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
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