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Effect of Troxerutin on Oxidative Stress Induced by Myocardial Ischemia / Reperfusion in Diabetic Rats
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Hatam Ahmadi    1, Homiera Hatami Nemati2 , Reza Badalzadeh3 |
1- Assistant Professor of animal physiology, Department of Basic Sciences, Farhangian University, Tehran, Iran, , hahmadi@cfu.ac.ir
2- Associate Professor of animal physiology, Department of Animal Biology, Faculty of Natural Sciences, Tabriz University, Tabriz, Iran
3- Associate Professor of physiology, Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran |
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Abstract: (1674 Views) |
Background and Aim: Diabetes is one of the major risk factors for ischemic heart disease. The aim of this study was to investigate the effect of antioxidant drug troxerutin (TXR) on ischemia-reperfusion-induced myocardial injury in experimental streptozotocin-induced diabetic rats.
Materials and Methods: Male Wistar rats (250-270 g) were divided into four groups including control, troxerutin, streptozotocin and streptozotocin + troxerutin groups. Diabetes was induced in the rats by intraperitoneal injection of 50 mg / kg streptozotocin and rats were studied for 10 weeks. Rats in the streptozotocin + tezroxerotin group received troxerotin by oral gavage for 4 weeks from the 7th week onwards. The hearts of the rats in all groups were placed in the Langendrov apparatus after separation from the body and subjected to local ischemia for 30 minutes followed by reperfusion for 60 minutes. The amount of lactate dehydrogenase enzyme in coronary artery as well as the parameters of superoxide dismutase and glutathione peroxidase in myocardial tissue during ischemia-reperfusion were measured using special kits.
Results: Body weight and the amount of superoxide dismutase and glutathione peroxidase enzymes were significantly decreased in the diabetic rats (P <0.05). Troxerutin in the streptozotocin + troxerutin group improved the levels of these enzymes to normal levels (P <0.05), whereas lactate dehydrogenase level decreased in this group (P <0.05).
Conclusion: In this study troxerutin reduced the severity of ischemia-reperfusion injury in the diabetic rats. |
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| Keywords: Troxerutin, Streptozotocin, Oxidative stress, Ischemia-reperfusion |
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Full-Text [PDF 1316 kb]
(510 Downloads)
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Type of Study: Original Research |
Subject:
Physiology and neurosciences
Received: 2020/02/16 | Accepted: 2021/01/14 | Published: 2022/03/7
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