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:: Volume 26, Issue 2 (Scientific Journal of Kurdistan University of Medical Sciences 2021) ::
SJKU 2021, 26(2): 12-24 Back to browse issues page
Histopathological effects of zinc oxide nanoparticles prepared by Vaccinium arctostaphylos ethanolic fruit extract on liver and pancreas of diabetic rats
Abolfazl Bayrami 1, Shadi Parvinroo2 , Shima Rahim pouran3 , Aziz Habibi Yengjeh4 , Farid Mohammadi Arvanagh2 , Madi Bayrami5
1- Department of Biology, Faculty of Science, University of Mohagheghe Ardabili, Ardabil, Iran , a_bayrami@uma.ac.ir
2- Department of Biology, Faculty of Science, University of Mohagheghe Ardabili, Ardabil, Iran
3- Social Determinants of Health Research Center, Ardabil University of Medical Sciences, Ardabil, Iran.
4- Department of Chemistry, Faculty of Science, University of Mohagheghe Ardabili, Ardabil, Iran
5- Department of Veterinary Medicine, Faculty of Veterinary Medicine, Azad University of Tabriz, Tabriz, Iran
Abstract:   (139 Views)
Background and Aim: The vast applications of nanotechnology in various fields including medicine, bring about the necessity to investigate the in vivo side effects of these materials. On this basis, we investigated the potential anti-diabetic activity of nanoparticles (NPs) along with toxicological effects on liver and pancreas tissue.
Materials and Methods: In this excremental research after preparation of ZnO nanoparticles and their characterization with SEM, EDX, and TEM, 30 rats were studied in 6 groups of 5 each. The groups included 1- Healthy control 2- Diabetic control 3- Diabetic - Insulin (10 U/kg) 4- Diabetic - Cranberry (150 mg/kg) 5- Diabetic-ZnO (8 mg/kg) 6- Diabetic-ZnO + extract (8 mg/kg). Diabetes was induced with alloxan monohydrate via intraperitoneal injection (170 mg/kg). Rats were treated intraperitoneal for 16 days and every four days examined for blood glucose levels, at the end of the treatment period, the liver and pancreatic tissues were analyzed by hematoxylin-eosin staining. Data were analyzed using two-way ANOVA and Tukey post hoc tests in SPSS.
Results: The analysis of nanoparticles revealed the capping of organic constituents on the surface of the biological nanoparticles. The assessment of serum samples displayed a significant decrease in blood glucose levels in the group that was treated by NPs prepared by extract when compared to that of the diabetic control group (p≤0/05). The histopathological analysis did not show any damages to the studied organs.
Conclusion: The results obtained in the present study revealed that the bio-synthesized nanoparticles not only significantly decreased the blood glucose level of diabetic rats but also had no toxic effects on the liver and pancreas tissues at the concentrations used in this study.
Keywords: Cranberry, Liver, Nanotechnology, Pancreas, Therapeutic, Toxicity
Full-Text [PDF 662 kb]   (94 Downloads)    
Type of Study: Research | Subject: General
Received: 2019/09/2 | Accepted: 2020/10/21 | Published: 2021/05/31
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Bayrami A, Parvinroo S, Rahim pouran S, Habibi Yengjeh A, Mohammadi Arvanagh F, Bayrami M. Histopathological effects of zinc oxide nanoparticles prepared by Vaccinium arctostaphylos ethanolic fruit extract on liver and pancreas of diabetic rats. SJKU. 2021; 26 (2) :12-24
URL: http://sjku.muk.ac.ir/article-1-5329-en.html


Volume 26, Issue 2 (Scientific Journal of Kurdistan University of Medical Sciences 2021) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
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