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:: Volume 26, Issue 2 (Scientific Journal of Kurdistan University of Medical Sciences 2021) ::
SJKU 2021, 26(2): 25-31 Back to browse issues page
Efficiency of nitroglycerine and diltiazem coadministration comparison with topical bethanechol and diltiazem in the treatment of chronic anal fissures: a randomized clinical trial
Baran Parhizkar1 , Parviz Esmaeilzadeh1 , Asrin Babahajian1 , Houshiyar Ghafory1 , Amirhosein Entezari 2
1- Liver and Digestive Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran
2- Liver and Digestive Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran , Amirhosein_entezari@yahoo.com
Abstract:   (136 Views)
  • Background and Aim: Anal fissure is one of the common anorectal disorders that there are various therapies for it. The aim of this study is to evaluate the effect of Nitroglycerin plus Diltiazem vs either topical Diltiazem and Bethanechol alone in the treatment of chronic anal fissure.
    Materials and Methods: The present randomized double-blind clinical trial was performed on 90 patients with chronic anal fissure referred to the gastroenterology clinic of Tohid Hospital, Sanandaj, Iran, from March 2016 to February 2017, That randomly were divided into three equal groups (n = 30): A: combination therapy (1% Nitroglycerin plus 5% Diltiazem gel), B: Diltiazem (5% Diltiazem gel) and C: Bethanechol (0.1% Bethanechol gel). The drugs were administered topically three times daily for 8 weeks. After 4 and 8 weeks’ administration wound condition, pain and bleeding were assessed. Data were analyzed by SPSS v.19 software with Chi-square test.
  • At the beginning of the study, there was no significant difference in mean age, sex, fissure location, hemorrhoids, bleeding, and pain between the three groups (P> 0.05). Four weeks after treatment, there was no significant difference between the three groups in terms of Wound healing (P = 0.41), pain (P = 0.10), and bleeding (P = 0.07). After 8 weeks, there was a significant difference for pain in the treatment groups (P = 0.04), so that in the diltiazem group, the pain was significantly decreased in comparison to Betanchenol and There was no significant difference between the three groups in the case of Wound healing (P = 0.10) and bleeding (P = 0.69).
  • Topical use of diltiazem is a more appropriate option for the treatment of chronic fissure than the other two drugs.
Keywords: Anal fissure, Drug treatment, Nitroglycerine Ointment, Diltiazem gel, bethanechol gel
Full-Text [PDF 941 kb]   (62 Downloads)    
Type of Study: Research | Subject: General
Received: 2019/07/22 | Accepted: 2020/10/3 | Published: 2021/05/31
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Parhizkar B, Esmaeilzadeh P, Babahajian A, Ghafory H, Entezari A. Efficiency of nitroglycerine and diltiazem coadministration comparison with topical bethanechol and diltiazem in the treatment of chronic anal fissures: a randomized clinical trial. SJKU. 2021; 26 (2) :25-31
URL: http://sjku.muk.ac.ir/article-1-5207-en.html


Volume 26, Issue 2 (Scientific Journal of Kurdistan University of Medical Sciences 2021) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
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