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:: Volume 23, Issue 2 (Scientific Journal of Kurdistan University of Medical Sciences 2018) ::
SJKU 2018, 23(2): 103-113 Back to browse issues page
The effects of crocin on the serum levels of sex hormone and NO in streptozotocin – induced diabetic rats.
Hananeh Bahojb Soldozi1 , Faramarz Jalili1 , Maryam Sohrabi2 , Zahra Keshtmand3 , Cyrus Jalili 4
1- Students Research Committee, KermanshahUniversity of Medical Sciences, Kermanshah, Iran.
2- Medical Biology Research Center, Kermanshah University of Medical Sciences,Kermanshah, Iran.
3- Department of Biology, Central Tehran Branch, Islamic Azad University, Tehran, Iran
4- Medical Biology Research Center, Kermanshah University of Medical Sciences,Kermanshah, Iran , cjalili@yahoo.com
Abstract:   (5682 Views)
Background and Aim: Diabetes can lead to reduced fertility in men by production of free radicals. Crocin (the effective component of saffron) with its antioxidant property can be effective in elimination of free radicals. We evaluated the effects of crocin on the reproductive parameters of the STZ –induced diabetic male Wistar rats.
Materials and Method: Rats were made diabetic with STZ (55 mg/kg). The rats were divided randomly into 8 groups of seven: control group (normal Saline), STZ induced diabetic group, groups receiving 12.5, 25 and 50 mg/kg doses of crocin and STZ induced diabetic groups receiving the same doses of the crocin. These animals were kept under experimental conditions for 30 days. LH, FSH, testosterone and insulin hormones are measured .The significance of the results was examined by ANOVA statistical method.
Results:
Groups receiving crocin and STZ simultaneously showed significant increase (P <0.05) in the levels of LH, FSH, testosterone and insulin hormones compared to the groups receiving STZ.
Conclusion: Crocin compensates for the most of degenerative effects of STZ-induced diabetes on the reproductive system of the male rats. It is a rich source of antioxidants and can positively affect most of the reproduction indexes in the rats in a dose depend manner.
Keywords: Crocin, Streptozocin, Rat, Diabetes.
 
Received: Nov 21, 2017     Accepted: Apr 8, 2018
Keywords: Crocin, Streptozocin, Rat, Diabetes.
Full-Text [PDF 260 kb]   (1771 Downloads)    
Type of Study: Original Research | Subject: General
Received: 2018/05/31 | Accepted: 2018/05/31 | Published: 2018/05/31
References
1. Piero M, Nzaro G, Njagi J. Diabetes mellitus-a devastating metabolic disorder. Asian J Biomed Pharm 2015; 40: 1-7. [DOI:10.15272/ajbps.v4i40.645]
2. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2010; 33: 62–9. [DOI:10.2337/dc10-S062]
3. Gao HX, Regier EE, Close KL. International Diabetes Federation World Diabetes Congress 2015. J Diabetes 2016; 8: 300–2. [DOI:10.1111/1753-0407.12377]
4. L'Heveder R, Nolan T. International diabetes federation. Diabetes Res Clin Pract 2013; 101: 349-51. [DOI:10.1016/j.diabres.2013.08.003]
5. Palmeira CM, Santos DL, Seiça R, Moreno AJ, Santos MS. Enhanced mitochondrial testicular antioxidant capacity in Goto-Kakizaki diabetic rats: role of coenzyme Q. Am J Physiol Cell Physiol 2001; 281: C1023-C8. [DOI:10.1152/ajpcell.2001.281.3.C1023]
6. Khaki A, Nouri M, Fathiazad F, Ahmadi-Ashtiani H, Rastgar H, Rezazadeh S. Protective effects of quercetin on spermatogenesis in streptozotocin-induced diabetic rat. J Med Plants 2009; 1: 57-64.
7. Ramalho-Santos J, Amaral S, Oliveira PJ. Diabetes and the impairment of reproductive function: possible role of mitochondria and reactive oxygen species. Curr Diabetes Rev 2008; 4: 46-54. [DOI:10.2174/157339908783502398]
8. Jiang GY. Practical Diabetes. 1nd ed. Beijing: People's Health Publishing House, 1996: 295.
9. Murray FT, Cameron DF, Vogel RB, Thomas RG, Wyss hU, Zauner CW. The pituitary‐testicular axis at rest and during moderate exercise in males with diabetes mellitus and normal sexual function. J Androl 1988; 9: 197-206. [DOI:10.1002/j.1939-4640.1988.tb01034.x]
10. Pitteloud N, Hardin M, Dwyer AA, Valassi E, Yialamas M, Elahi D, et al. Increasing insulin resistance is associated with a decrease in Leydig cell testosterone secretion in men. J Clin Endocrinol Metab 2005; 90: 2636-41. [DOI:10.1210/jc.2004-2190]
11. Cameron DF, Murray FT, Drylie DD. Interstitial compartment pathology and spermatogenic disruption in testes from impotent diabetic men. Anat Rec 1985; 213: 53-62. [DOI:10.1002/ar.1092130108]
12. Vignon F, Le Faou A, Montagnon D, Pradignac A, Cranz C, Winiszewsky P, et al. Comparative study of semen in diabetic and healthy men. Diabete Metab 1991; 17: 350-4.
13. Ballester J, Munõz MC, Domínguez J, Rigau T, Guinovart JJ, Rodríguez‐Gil JE. Insulin‐dependent diabetes affects testicular function by FSH‐and LH‐linked mechanisms. J Androl 2004; 25: 706-19. [DOI:10.1002/j.1939-4640.2004.tb02845.x]
14. Hagh Nazari S, Keifi N, editors. Saffron and various fraud matter in its production and trade. 2nd International Symposium on Saffron Biology and Technology. 2006 Oct. 28–30, Mashhad, Iran.
15. Hosseinzadeh H, Ziaee T, Sadeghi A. The effect of saffron, Crocus sativus stigma, extract and its constituents, safranal and crocin on sexual behaviors in normal male rats. Phytomedicine 2008; 15: 491-5. [DOI:10.1016/j.phymed.2007.09.020]
16. Singla RK, Bhat VG. Crocin: an overview. Glo J Pharmaceu Sci 2011; 1: 281-6.
17. Bathaie SZ, Bolhassan A, Tamanoi F. Anticancer effect and molecular targets of saffron carotenoids. Enzymes 2014; 36: 57-86. [DOI:10.1016/B978-0-12-802215-3.00004-5]
18. Imenshahidi M, Razavi BM, Faal A, Gholampoor A, Mousavi SM, Hosseinzadeh H. Effects of crocin treatment on desoxycorticosterone acetate (doca)-salt hypertensive rats. Iran J Basic Med Sci 2014; 17: 9-13.
19. Jalili C, Tabatabaei H, Kakaberiei S, Roshankhah S, Salahshoor MR. Protective role of Crocin against nicotine-induced damages on male mice liver. Int J Prev Med 2015; 6: 92. [DOI:10.4103/2008-7802.165203]
20. Salahshoor MR, Khashiadeh M, Roshankhah S, Kakabaraei S, Jalili C. Protective effect of crocin on liver toxicity induced by morphine. Res Pharm Sci 2016; 11: 120.
21. Modaresi M, Mesripour M, Asadi Margh Maleki M, Hamedanian MK. Effect of Saffron (Crocus Sativus) extract on level of FSH, LH and testosterone in mice. J Zanjan Univ Med Sci 2008; 16: 11-17. [In Persian]
22. Rafiee Z, Jalili F, Sohrabi M, Jalili C. Effects of hydro-alcoholic extract of falcaria vulgaris on pancreas tissue in streptozotocin-induced diabetic rats. Iran J Endocrinol Metab 2017; 19: 91-8. [In Persian]
23. Jalili C, Ahmadi S, Roshankhah S, Salahshoor M. Effect of Genistein on reproductive parameter and serum nitric oxide levels in morphine-treated mice. Int J Reprod Biomed 2016; 14: 95–102. [DOI:10.29252/ijrm.14.2.95]
24. Peunova N, Enikolopov G. Amplification of calcium-induced gene transcription by nitric oxide in neuronal cells. Nature 1993; 364: 450-3. [DOI:10.1038/364450a0]
25. Lewis S, Donnelly E, Sterling E, Kennedy M, Thompson W, Chakravarthy U. Nitric oxide synthase and nitrite production in human spermatozoa: evidence that endogenous nitric oxide is beneficial to sperm motility. Mol Hum Reprod 1996; 2: 873-8. [DOI:10.1093/molehr/2.11.873]
26. Roshankhah SH, Salahshoor MR, Jalili F, Karimi F, Sohrabi M, Jalili C. Crocin effects on the nicotine-induced ovary injuries in female rat. Int J Life Sci Pharma Res 2017; 7: 1-8.
27. Hellstrom WJ, Bell M, Wang R, Sikka SC. Effect of sodium nitroprusside on sperm motility, viability, and lipid peroxidation. Fertil Steril 1994; 61: 1117-22. [DOI:10.1016/S0015-0282(16)56766-1]
28. Sengoku K, Tamate K, Yoshida T, Takaoka Y, Miyamoto T, Ishikawa M. Effects of low concentrations of nitric oxide on the zona pellucida binding ability of human spermatozoa. Fertil Steril 1998; 69: 522-7. [DOI:10.1016/S0015-0282(97)00537-2]
29. Chen M, Dou J. Diabetes and gonadal disorders. JTIM 2014; 2: 119-23.
30. Bal R, Türk G, Tuzcu M, Yilmaz O, Ozercan I, Kuloglu T, et al. Protective effects of nanostructures of hydrated C 60 fullerene on reproductive function in streptozotocin-diabetic male rats. Toxicology 2011; 282: 69-81. [DOI:10.1016/j.tox.2010.12.003]
31. Soerensen RR, Johannsen TH, Skakkebaek NE, Rajpert-De Meyts E. Leydig cell clustering and Reinke crystal distribution in relation to hormonal function in adult patients with testicular dysgenesis syndrome (TDS) including cryptorchidism. Hormones (Athens) 2016; 15: 518-26. [DOI:10.14310/horm.2002.1708]
32. Samadi H, Javadi S, Asri S. Evaluation of the effects of crocin on the serum levels of glucose, insulin, urea, creatinine and β2m in healthy and streptozotocin-induced diabetic rats. Urmia Med J 2015; 26: 802-12. [In Persian]
33. Asadi MH, Zafari F, Sarveazad A, Abbasi M, Safa M, Koruji M, et al. Saffron improves epididymal sperm parameters in rats exposed to cadmium. Nephrourol Mon 2014; 6: 1-6.
34. Tarantilis PA, Polissiou M, Manfait M. Separation of picrocrocin, cis-trans-crocins and safranal of saffron using high-performance liquid chromatography with photodiode-array detection. J Chromatogr A 1994; 664: 55-61. [DOI:10.1016/0021-9673(94)80628-4]
35. Duru NK, Morshedi M, Oehninger S. Effects of hydrogen peroxide on DNA and plasma membrane integrity of human spermatozoa. Fertil steril 2000; 74: 1200-7. [DOI:10.1016/S0015-0282(00)01591-0]
36. Salahshoor MR, Khazaei M, Jalili C, Keivan M. Crocin improves damage induced by nicotine on a number of reproductive parameters in male mice. Int J Fertil Steril 2016; 10: 71-8.
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Bahojb Soldozi H, Jalili F, Sohrabi M, Keshtmand Z, Jalili C. The effects of crocin on the serum levels of sex hormone and NO in streptozotocin – induced diabetic rats.. SJKU 2018; 23 (2) :103-113
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Volume 23, Issue 2 (Scientific Journal of Kurdistan University of Medical Sciences 2018) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
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