Background and Aim: when two or more drugs are prescribed simultaneously for different purposes such as treatment, prevention or diagnosis, they may exert beneficial or adverse effects on one another. Sometimes drug interactions may result in undesirable or life threatening reactions. The aim of this study was to assess the rate of drug interactions in the prescriptions of physicians in Kurdistan Province in 2000.
Materials and Methods: This is a descriptive study. 1800 Medical prescriptions (out of 12386) which had drug interactions, were selected. The data were collected from checklists and prescriptions and were analyzed by means of SPSS software.
Result : In our study drug interactions were detected in 8.5 percent of all prescriptions in Kurdistan province. In Sanandaj City the rate of interactions was 9.34 percent which was the highest and Divandarah with 7.1 percent had the lowest rate of drug Interactions. 89.4 percent of all drug interactions were detected in the prescriptions of male physicians and 10.6 percent in those of female physicians. On the whole, the rate of severe, intermediate and slight interactions were 15.6%, 42.6% and 41.8% respectively.
The prevalence rates of the most common interactions of intermediate, severe and slight types were those of atenolol with NSAIDS in 11.9%, penicillin with tetracycline or doxicycline in 5.5%, and asprin with diphenhydramin in 4% of the all cases of drug interactions, respectively.
Conclusion : It seems that educational plans for physicians including self-learning, workshops, conferences and assessment of prescriptions can be useful measures to avoid such interactions. If drug interactions are to be avoided, establishment of data gathering networks together with centers for assessment of medical prescriptions in medical schools and education of the medical students as to writing proper and logical prescriptions are necessary before internship.
Key words : Medical doctor (M.D), Drug interaction, Prescription