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Oxidative stress indecies in uncomplicated type 2 diabetic patients
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Jaafar Nourooz-Zadeh   1, Gholam Ali Hafizi , Mohammad Hasan Khadem Ansari , Kamran Kayvan Pajoh |
| 1- , Jnouroozzadeh@;yahoo.co.uk |
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Abstract: (14045 Views) |
| Background and Aim: Type 2 diabetic patients are at increased risk for the development of complications including cardiovascular, nephropathy and neuropathy. The increased risk is not fully explainable by factors such as dyslipidemia and hypertension. Therefore, oxidative stress has proposed as an alternative explanation although the underlying mechanism(s) is not clearly understood. The objective of the present study was to evaluate plasma prooxidant/antioxidant status in uncomplicated type 2 diabetic patients. An aged-matched group of non-diabetics was used as control group.
Materials and Methods: In this case-control study, 20 type 2 diabetic patients 7 males and 13 females (44.2±0.7 years) and 20 non-diabetic patients 12 males and 8 females (43.2±0.9 years) were entered into this study. Plasma malonedialdehyde, total glutathione, catalase and superoxide dismutase were dertermined spectrophotometrically and level of vitamin E was measured by HPLC. Statistical analyses were carried out by means of the SPSS-Win version 10 soft-ware package.
Results: The glutathione levels and vitamin E/triglyceride ratios in diabetic patients were lower than those of non diabetics (148.8±15.5 nmol/L vs 192.9±54.4 nmol/L p<0.05 and 14.4±1.6 mol/mmol vs 17.0±1.1 mol/mmol p<0.05 repsectively). Compared to control group, diabetic patients exhibited slightly higher levels of malonedialdehyde (196.1±10.7 nmol/L vs 175.2±20.4 nmol/L). Catalase content and superoxide dismutase revealed different activities in diabetic and control groups but the differences failed to show any statistical significance (571.9±65.3 g/L vs 541.1±67.4 g/L and 0.29±0.06 OD vs 0.26±0.01 OD, respectively).
Conclusion: This study revealed that plasma markers of oxidative stress, when compared with control group, were slightly altered in uncomplicated type 2 diabetic patients. These data provide additional support for the hypothesis that oxidative stress precedes the development of diabetic complications. |
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| Keywords: Oxidative stress, Diabetes, Antioxidants, Lipid peroxidation |
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Full-Text [PDF 209 kb]
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Type of Study: Original Research |
Subject:
General
Received: 2009/05/12 | Published: 2006/09/15
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