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:: Volume 13, Issue 4 (Scientific Journal of Kurdistan University of Medical Science 2009) ::
SJKU 2009, 13(4): 16-22 Back to browse issues page
The effect of chronic L-Carnitne supplementation on plasma glucose and lactate during exercise
Mojtaba Izadi 1, Anoosh Aghdami , Davoud Khorshidi , Saba Ahmadi Dr, Hosain Doali , Fatemeh Kyani
1- , izadimojtaba2006@yahoo.com
Abstract:   (10479 Views)
Background and Aim: In skeletal muscle, carnitine plays an essential role in the translocation of long-chain fatty-acids into the mitochondrial matrix for subsequent beta-oxidation. Despite an abundance of literature describing the basic mechanisms of action of L-carnitine metabolism, there remains some uncertainty regarding the effects of oral L-carnitine supplementation on metabolism and exercise performance in normal subjects. This study examined the effects of chronic L-carnitine supplementation on glucose and lactate concentration, heart rate and aerobic capacity during submaximal cycling. Material and Methods: Thirty healthy and male students cycled for 20 min at 70% VO2 max before and after 3 weeks (3g daily) L-carnitine (experimental) and placebo (control) supplementation. Blood samples were taken immediately after each exercise for the purpose of calculation plasma glucose and Lactate concentration, lactate dehydrogenase activity (LDH). A two-way repeated measure ANOVA was used to determine significant differences between the two groups (p<0.05). Result: The finding of our study showed that L-carnitine supplementation had no influence on plasma glucose and lactate. Also rest and rest heart rate, VO2 max and LDH activity was equal in pre and posttests (p<0.05). All variables were unaffected in the control trial. Conclusion: Three weeks L-carnitine supplementation had no effect on substrate and carbohydrate metabolism. Also, L-carnitine supplementation would be unlikely to be associated with the enhanced exercise performance. Key words: L-carnitine, glucose, lactate, metabolism, aerobic exercise Conflict of Interest: Nill Received: November 23, 2008 Accepted: January 19, 2009
Keywords: L-carnitine, glucose, lactate, metabolism, aerobic exercise
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Type of Study: Research | Subject: General
Received: 2009/05/2
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Izadi M, Aghdami A, Khorshidi D, Ahmadi S, Doali H, Kyani F. The effect of chronic L-Carnitne supplementation on plasma glucose and lactate during exercise. SJKU. 2009; 13 (4) :16-22
URL: http://sjku.muk.ac.ir/article-1-96-en.html


Volume 13, Issue 4 (Scientific Journal of Kurdistan University of Medical Science 2009) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
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