|
The effect of chronic L-Carnitne supplementation on plasma glucose and lactate during exercise
|
Mojtaba Izadi   1, Anoosh Aghdami , Davoud Khorshidi , Saba Ahmadi , Hosain Doali , Fatemeh Kyani |
| 1- , izadimojtaba2006@yahoo.com |
|
|
Abstract: (14387 Views) |
| Background and Aim: In skeletal muscle, carnitine plays an essential role in the translocation of long-chain fatty-acids into the mitochondrial matrix for subsequent beta-oxidation. Despite an abundance of literature describing the basic mechanisms of action of L-carnitine metabolism, there remains some uncertainty regarding the effects of oral L-carnitine supplementation on metabolism and exercise performance in normal subjects. This study examined the effects of chronic L-carnitine supplementation on glucose and lactate concentration, heart rate and aerobic capacity during submaximal cycling.
Material and Methods: Thirty healthy and male students cycled for 20 min at 70% VO2 max before and after 3 weeks (3g daily) L-carnitine (experimental) and placebo (control) supplementation. Blood samples were taken immediately after each exercise for the purpose of calculation plasma glucose and Lactate concentration, lactate dehydrogenase activity (LDH). A two-way repeated measure ANOVA was used to determine significant differences between the two groups (p<0.05).
Result: The finding of our study showed that L-carnitine supplementation had no influence on plasma glucose and lactate. Also rest and rest heart rate, VO2 max and LDH activity was equal in pre and posttests (p<0.05). All variables were unaffected in the control trial.
Conclusion: Three weeks L-carnitine supplementation had no effect on substrate and carbohydrate metabolism. Also, L-carnitine supplementation would be unlikely to be associated with the enhanced exercise performance.
Key words: L-carnitine, glucose, lactate, metabolism, aerobic exercise
Conflict of Interest: Nill
Received: November 23, 2008 Accepted: January 19, 2009 |
|
| Keywords: L-carnitine, glucose, lactate, metabolism, aerobic exercise |
|
|
Full-Text [PDF 126 kb]
(2463 Downloads)
|
Type of Study: Original Research |
Subject:
General
Received: 2009/05/2 | Published: 2009/03/15
|
|
|
|
|
|
|
| Send email to the article author |
|
|
|
| Add your comments about this article |
|
|
|
