ABSTRACT Background and Aim:Varicocele is defined as the abnormal dilatation and tortuosity of the pampiniform plexus veins within the spermatic cord. It is observed in approximately 15% of the general population. Despite its relatively high prevalence and its established association with impaired spermatogenesis and steroidogenesis, its specific impact on severe male infertility factors requires further investigation. This study aimed to determine the prevalence of varicocele in infertile men diagnosed with non-obstructive azoospermia who were referred to the Sanandaj infertility center between 2020 and 2022. Materials and methods: This cross-sectional (descriptive-analytical) study was conducted on 170 infertile men diagnosed with non-obstructive azoospermia at the Sanandaj infertility center. Data from patients with available medical records and a confirmed diagnosis of azoospermic infertility were analyzed. The diagnosis of azoospermia was based on comprehensive patient history, clinical examination, and laboratory tests. A significance level of 5% was considered for this study. Results: The results indicated that among the patients with varicocele, 14 individuals (14.1%) presented with bilateral varicocele, 14 (14.1%) with right-sided varicocele, and 59 (67.8%) with left-sided varicocele. Regarding varicocele grade, 25 patients (28.7%) had grade I, 34 (39.1%) had grade II, and 28 (32.2%) had grade III. Overall, 72 participants (42.4%) reported a history of smoking, and 26 (15.3%) reported a history of alcohol consumption. Conclusion: The findings of this study suggest that environmental variables such as smoking and alcohol consumption, along with a family history of varicocele and demographic factors like age and occupation, may be associated with the prevalence of varicocele. However, the epidemiology of varicocele is not yet fully understood. Therefore, large-scale, well-designed studies that include the assessment of key clinical factors are necessary to fully elucidate the epidemiological aspects of this condition.