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:: Volume 17, Issue 3 (Scientific Journal of Kurdistan University of Medical Sciences 2012) ::
SJKU 2012, 17(3): 1-10 Back to browse issues page
Influence of nicotine on muscimol state-dependent memory in the step-down passive avoidance test
Zahra Bashiri 1, Shahrbanoo Oryan Dr2, Bahareh Pakpour Dr3, Majid Navaeian Dr4, Morteza Piri Dr 5
1- Science and Research Branch, Islamic Azad University, Tehran
2- Professor Science and Research Branch, Islamic Azad University, Tehran
3- Assistant Professor Central Tehran branch, Islamic Azad University, Tehran
4- Assistant Professor Islamic Azad University, Shahr-e-rey branch
5- Assistant Professor Islamic Azad University, Ardabil branch , biopiri@yahoo.com
Abstract:  
ABSTRACT Background and Aim: Due to overlapping distribution of GABA receptors with nicotinic receptors in some parts of brain such as dorsal hippocampus, the functional interactions between nicotinic acetylcholine and GABA ergic systems in cognitive control seems possible. The present study evaluated the possible role of nicotinic receptors of the dorsal hippocampus in muscimol (the GABAA receptor agonist) induced amnesia and muscimol state-dependent memory in adult male mice. Material and Methods: This experimental study included 185 adult male NMRI mice. The drugs used in this study were muscimol and nicotine. The mice were anaesthetized and placed into a stereotaxic apparatus. Cannulas were implanted bilaterally in the CA1 regions of the dorsal hippocampus. After a seven day recovery period, the behavioral testing was performed by using inhibitory avoidance task. Prolongation of the step-down latency was measured as a criterion for the assessment of memory retention. Results: Post-training administration of muscimol (0.15 and 0.075 µg/mouse) decreased the memory retrieval. The memory impairment induced by muscimol (0.15µg/mouse) was completely reversed by administration of muscimol or nicotine (1.5 and 1 µg/mouse) on the test day, which suggests muscimol, induced state-dependent memory. Conclusion: These results suggested that nicotinic receptors of the dorsal hippocampus may play an important role in muscimol -induced amnesia and muscimol state-dependent memory. Key words: Muscimol, Nicotine, State-dependent learning, Inhibitory avoidance learning, Mice Received: Dec 24, 2011 Accepted: Apr 26, 2012
Keywords: Muscimol, Nicotine, State-dependent learning, Inhibitory avoidance learning, Mice
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Type of Study: Research | Subject: General
Received: 2012/09/25
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Volume 17, Issue 3 (Scientific Journal of Kurdistan University of Medical Sciences 2012) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
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