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:: Volume 16, Issue 3 (Scientific Journal of Kurdistan University of Medical Sciences 2011) ::
SJKU 2011, 16(3): 56-64 Back to browse issues page
Survival analysis of the patients with acute myocardial infarction by use of penalized splines
Daem Roshani 1, Anoshirvan Kazemzadeh Dr 2, Ebrahim Hajizadeh Dr3, Firooz Amani Dr4
1- Tarbiat Modares University
2- 2. Professor Tarbiat Modares University , kazem_an@modares.ac.ir
3- 3. Associate Professor Tarbiat Modares University
4- 4. Assistant Professor Ardabil University of Medical Sciences
Abstract:  
ABSTRACT Background and aim: Cardiovascular diseases are one of the most common causes of death and also major health problems in the world. The classical methods such as Cox regression are used in most medical studies on survival distribution, while this model assumes a linear relationship between log hazard ratio and risk factors which is not useful in many cases. The present study was performed to use the method of penalized splines to analyze the survival rate of the patients who had acute myocardial infraction. Materials and Methods: This research was a prospective descriptive-analytical study of longitudinal type which included 650 patients with acute myocardial infarction. Patients were followed for one year from the moment of diagnosis of MI, for survival analysis. The collected data were recorded in a check-list for every patient. Two different multivariate methods, proportional hazard regression and Cox model with penalized splines were used. Data analysis was carried out using R version 2.12 software and significant levels were considered 0.05. Results: The mortality rate of the patients in a period of one year was 10.3% (67patients). History of smoking, hypertension, diabetes, hyperlipidemia, arrhythmia and heart block were detected in 48%, 33.4%, 17.7%, 15.3%, 30% and 10.3% of the patient respectively. Based on Cox model with penalized splines the factors affecting survival rate were age, ejection fraction and use of streptokinase. Conclusion: Knowledge of the survival rate and factors affecting survival in the patients with acute MI can be used to provide the patients with valuable services, and to take measures to control and reduce mortality rate which can lead to increased life expectancy of these patients. Key words: Survival, Myocardial infarction, Cox model, Penalized splines Conflict of Interest: Nill Received: Feb 6, 2011 Accepted: Jul 7, 2011
Keywords: Survival, Myocardial infarction, Cox model, Penalized splines
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Type of Study: Research | Subject: General
Received: 2011/10/6
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Volume 16, Issue 3 (Scientific Journal of Kurdistan University of Medical Sciences 2011) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
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