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:: Volume 13, Issue 3 (Scientific Journal of Kurdistan University of Medical Sciences 2008) ::
SJKU 2008, 13(3): 53-61 Back to browse issues page
Assessment of genetic pattern of mycobactrium TB isolated from Iranian and Afghan TB patients by means of VNTR typing
Elahe Tajadin , Parisa Farnia Dr 1, Mohammad Kargar Dr, Jamileh Nawrozi Dr, Rashid Ramazanzadeh Dr, Mehdi Kazempour , Mohammad Reza Masjedi Dr, Ali Akbar Velayati Dr
1- , pfarnia@hotmail.com
Abstract:   (8207 Views)

 

Background and Aim: The aim of this study was to identify genetic pattern of mycobacterium TB strains isolated from Iranian and Afghan TB cases by VNTR method.

Material and Methods: 191 strains of mycobacterium TB isolated from pulmonary TB patients were typed by use of VNTR method from 2006 to 2008. SPSS soft ware was used for data analysis. The allelic diversity of each primer was measured in 2 groups.

Result: The antibiotic resistance was more common in Afghan patients (p≥0.5). Comparison of allele diversity between Iranian Afghan cases revealed VTNR pattern was also more common among Afghan TB cases, except for ETR-E locus that had more variation. Based on differentiation index of all strains, ETR-A locus identified as the most distinctive (HGI≥0.6) ETR-B, ETR- C, ETR-E, ETR-F, MPTR-A loci as median distinctive loci (HGI≥0.4-0.6) and ETR-D as the weakest distinctive locus (HGI=0).

Conclusion: VNTR method is simple, quick, and very stable and is useful for epidemiological studies.

 

Conflict of Interest: Nill

Received: May 19, 2008      Accepted: August 2, 2008

Keywords: Iran, Afghan, Mycobacterium TB
Full-Text [PDF 175 kb]   (1239 Downloads)    
Type of Study: Research | Subject: General
Received: 2009/04/11
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Tajadin E, Farnia P, Kargar M, Nawrozi J, Ramazanzadeh R, Kazempour M, et al . Assessment of genetic pattern of mycobactrium TB isolated from Iranian and Afghan TB patients by means of VNTR typing. SJKU. 2008; 13 (3) :53-61
URL: http://sjku.muk.ac.ir/article-1-52-en.html


Volume 13, Issue 3 (Scientific Journal of Kurdistan University of Medical Sciences 2008) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
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