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:: Volume 16, Issue 1 (Scientific Journal of Kurdistan University of Medical Sciences 2011) ::
SJKU 2011, 16(1): 10-19 Back to browse issues page
Effect of interleukin-12 p40 subunit gene 3’-untranslated region polymorphism in chronic HCV infection
Pedram Azimzadeh 1, Seyed Reza Mohebbi Dr 2, Sara Romani 3, Hamed Naghoosi 3, Mohsen Vahedi 3, Shabnam Kazemian 3, Faramarz Derakhshan Dr4, Mohammad Reza Zali Dr5
1- Shahid Beheshti Universityof Medical Sciences
2- Shahid Beheshti University of Medical Sciences , srmohebbi@rigld.ir
3- Shahid Beheshti University of Medical Sciences
4- Associate Professor Shahid Beheshti University of Medical Sciences
5- Professor دانشگاه علوم پزشکی شهید بهشتی
Abstract:  
ABSTRACT Background and Aim: Production of unusual cytokine levels in hepatitis C infection appears to be associated with progression of the disease, persistence of the virus in host, and establishment of chronic disease. Interleukin-12 as a heterodimeric immunoregulating cytokine is important in the generation of a Th1-based immune response. In this study we investigated the role of IL-12B 3′UTR polymorphism in susceptibility to chronic hepatitis C infection. Material and Methods: A total of 126 chronic hepatitis C patients and 136 healthy blood donors were genotyped for IL12-p 40- 3′ UTR polymorphism. Genotyping was carried out by PCR-RFLP method. The results were confirmed by analyzing 10 % of the samples by direct sequencing. Results: We found no significant differences in genotype and allele frequencies of the 3’UTR polymorphism between chronic hepatitis C patients and healthy controls. Conclusion: There was no association between IL12B-3’UTR polymorphism and chronic hepatitis C infection.Our study can be useful in regard to the factors regulating IL-12 production, and its consequent impact on chronic hepatitis C infection susceptibility in Iranian population. Key words: Chronic hepatitis C, Polymorphism, IL12-p40, 3′UTR Conflict of Interest: Nill Received: Aug 16, 2010 Accepted: Dec 28, 2010
Keywords: Chronic hepatitis C, Polymorphism, IL12-p40, 3′UTR
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Type of Study: Research | Subject: General
Received: 2011/05/10
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Volume 16, Issue 1 (Scientific Journal of Kurdistan University of Medical Sciences 2011) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
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