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Relationship between vitamin D plasma level and Foxp3 gene expression among rheumatoid arthritis patients
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Parisa Zafari1   , Shayan Mostafaei2 , Nasrin Iranshahi1 , Cyrus Jalili3 , Mahdi Taghadosi4 |
1- Student Research Committee, Medical school, Kermanshah University of Medical Sciences, Kermanshah, Iran.
2- Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
3- Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
4- Department of Immunology, Kermanshah University of Medical Sciences, Kermanshah, Iran , mtaghad@gmail.com |
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Abstract: (4984 Views) |
Background and Aim: Rheumatoid arthritis (RA) is an autoimmune disease. It seems that the function of regulatory T cells (Tregs) is compromised in RA. Foxp3 is a critical transcription factor of these cells. The aim of this study was to determine the relationship of vitamin D plasma level with Foxp3 gene expression in the patients with RA.
Material and Methods: 18 untreated RA patients and 41 healthy people participated in this study. Plasma levels of vitamin D were measured by competitive ELISA method. Foxp3 gene expression was also determined by using realtime PCR technique.
Results: The expression of Foxp3 gene was significantly lower in RA patients compared to that in the healthy controls (p<0.001) .There was no significant relationship between vitamin D plasma levels with the rate of Foxp3 gene expression.
Conclusion: We found low levels of vitamin D could not affect the expression of Foxp3 gene. It seems that vitamin D deficiency cannot be considered as an effective environmental factor in the pathogenesis of RA.
Keywords: Vitamin D, Foxp3, Rheumatoid arthritis.
Received: Jul 2, 2017 Accepted: Sep 24, 2017 |
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| Keywords: Vitamin D, Foxp3, Rheumatoid arthritis. |
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Full-Text [PDF 2918 kb]
(1168 Downloads)
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Type of Study: Original Research |
Subject:
General
Received: 2018/01/23 | Accepted: 2018/01/23 | Published: 2018/01/23
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