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:: Volume 22, Issue 6 (Scientific Journal of Kurdistan University of Medical Sciences 2018) ::
SJKU 2018, 22(6): 40-48 Back to browse issues page
Relationship between vitamin D plasma level and Foxp3 gene expression among rheumatoid arthritis patients
Parisa Zafari 1, Shayan Mostafaei 2, Nasrin Iranshahi 1, Cyrus Jalili 3, Mahdi Taghadosi * 4
1- Student Research Committee, Medical school, Kermanshah University of Medical Sciences, Kermanshah, Iran.
2- Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
3- Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
4- Department of Immunology, Kermanshah University of Medical Sciences, Kermanshah, Iran , mtaghad@gmail.com
Abstract:   (992 Views)
Background and Aim: Rheumatoid arthritis (RA) is an autoimmune disease. It seems that the function of regulatory T cells (Tregs) is compromised in RA. Foxp3 is a critical transcription factor of these cells. The aim of this study was to determine the relationship of vitamin D plasma level with Foxp3 gene expression in the patients with RA.
Material and Methods: 18 untreated RA patients and 41 healthy people participated in this study. Plasma levels of vitamin D were measured by competitive ELISA method. Foxp3 gene expression was also determined by using realtime PCR technique.
Results: The expression of Foxp3 gene was significantly lower in RA patients compared to that in the healthy controls (p<0.001) .There was no significant relationship between vitamin D plasma levels with the rate of Foxp3 gene expression.
Conclusion: We found low levels of vitamin D could not affect the expression of Foxp3 gene. It seems that vitamin D deficiency cannot be considered as an effective environmental factor in the pathogenesis of RA.
Keywords: Vitamin D, Foxp3, Rheumatoid arthritis.
 
Received: Jul 2, 2017     Accepted: Sep 24, 2017
Keywords: Vitamin D, Foxp3, Rheumatoid arthritis.
Full-Text [PDF 2918 kb]   (296 Downloads)    
Type of Study: Research | Subject: General
Received: 2018/01/23 | Accepted: 2018/01/23 | Published: 2018/01/23
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Zafari P, Mostafaei S, Iranshahi N, Jalili C, Taghadosi M. Relationship between vitamin D plasma level and Foxp3 gene expression among rheumatoid arthritis patients. SJKU. 2018; 22 (6) :40-48
URL: http://sjku.muk.ac.ir/article-1-3753-en.html


Volume 22, Issue 6 (Scientific Journal of Kurdistan University of Medical Sciences 2018) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
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