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:: Volume 22, Issue 4 (Scientific Journal of Kurdistan University of Medical Sciences 2017) ::
SJKU 2017, 22(4): 18-26 Back to browse issues page
Evaluation of demographic and behavioral characteristics of patients using non-steroidal, anti-inflammatory and combinatory drugs related with Upper Gastrointestinal Bleeding
Vahid Yousefinejad Dr1, Nazila Darvishi Dr2, Amir Taheri Dr3, Asrin Babahajian 4, Hoshiar Ghafory 5, Farhad Manoochehri 6, Roozbeh Fakhimi 6, Naser Reshadmanesh 7, Farshad Sheikhesmaili Dr 8
1- Liver and Digestive Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran.
2- PhD candidate of Nutrition, Faculty of Nutrition Science and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
3- Gastroenterologist, Liver and Digestive Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran.
4- Master of Anatomical Sciences, Liver and Digestive Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran.
5- Master of Biochemistry Science, Liver and Digestive Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran.
6- Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran.
7- Master of Environmental health, Liver and Digestive Research Center, Kurdistan University of Medical Sciences
8- Liver and Digestive Research Center, Kurdistan University of Medical Sciences , Dr_S_Smaili@yahoo.com
Abstract:   (1204 Views)
Background and Aim: Use of nonsteroidal anti-inflammatory drugs (NSAIDs) is the second most common cause of peptic-ulcer and a common cause of upper gastrointestinal bleeding (UGIB). The aim of this study was to evaluate demographic and behavioral characteristics of the hospitalized patients with UGIB who had been using NSAIDs, in Tohid hospital in Sanandaj, in Iran.
Material and Method: This descriptive, analytical study, included patients hospitalized in gastroenterology ward of Tohid Hospital due to UGIB and with history of using NSAIDs and related compounds (from February 2015 to February 2016). We used a questionnaire to record demographic, social, cultural and clinical characteristics of the subjects. Endoscopy was performed to determine causes of UGIB. Data were analyzed by using SPSS software.
Results: 60 patients were men (58.3%) and 43 were women (41.7%) with the mean age of 52.85±20.03. 8.4% of subjects had a family history of peptic ulcers in their first degree relatives, 26.9% and 6.8% had history of smoking and drinking alcoholic beverages respectively. 53.3% of the subjects had history of underlying disease of which chronic heart disease was the most frequent disorder (36%). The most frequent drugs used by the patients were aspirin and ibuprofen (58.3% and 42.7%, respectively). UGIB associated with aspirin use was more prevalent among the men than women. The main cause of bleeding (67%) was ulcer .There were no significant differences between causes of bleeding and use of NSAIDs, gender, age and age range of the patients. Also there was no significant difference in the mean age between both sexes (P> 0.5).
Conclusion: Considering the role of NSAIDs in UGIB, provision of necessary training for the correct use of NSAIDs (according to indications) and measures to eradicate H.Pylori infection will result in significant decrease in morbidity and mortality from UGIB in these patients.
Keywords: Nonsteroidal anti-inflammatory drugs, Upper gastrointestinal bleeding,  Demographic and behavioral characteristics.
Received: Jan 30, 2017       Accepted: Jun 17, 2017
Keywords: Nonsteroidal anti-inflammatory drugs, Upper gastrointestinal bleeding, Demographic and behavioral characteristics.
Full-Text [PDF 203 kb]   (342 Downloads)    
Type of Study: Research | Subject: General
Received: 2017/09/18 | Accepted: 2017/09/18 | Published: 2017/09/18
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Yousefinejad V, Darvishi N, Taheri A, Babahajian A, Ghafory H, Manoochehri F, et al . Evaluation of demographic and behavioral characteristics of patients using non-steroidal, anti-inflammatory and combinatory drugs related with Upper Gastrointestinal Bleeding. SJKU. 2017; 22 (4) :18-26
URL: http://sjku.muk.ac.ir/article-1-3393-en.html


Volume 22, Issue 4 (Scientific Journal of Kurdistan University of Medical Sciences 2017) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
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