Background and Aim: Liver has a major role in protection of human against various toxins and drugs. Cholestasis can be defined as impairment of the bile flow which can lead to increased oxidant stress, hepatocyte damage and finally cirrhosis. Selegiline is commonly used in management of Parkinson's disease. It has neuroprotective, antiapoptic and antioxidant properties. The aim of this study was to evaluate the effect of selegiline on liver cholestasis induced by bile duct ligation (BDL) in the rats.
Material and Methods: 30 male Wistar rats were randomly divided into 5 groups (n= 6) including saline, sham + saline, BDL + saline, BDL + Selegiline (0.15 mg/kg) and Selegiline (0.15 mg/kg). Under general anesthesia and sterile condition, laparatomy was done, and bile duct was ligated. After 14 days, liver function tests, serologic tests and serum TNF-α were performed for all groups after taking blood samples. The results were analyzed by one-way ANOVA.
Results: The results of the this study showed that selegiline significantly increased Alb, AST, ALT and ALP in BDL selegiline group compared to BDL+ saline. Also, when compared to saline group, selegiline significantly increased PT.
Conclusion: Selegiline in cholestatic rat model did not show a protective effect on the liver cells and in some cases exacerbated the symptoms.
Key words: Liver damage, Cholestasis, Selegiline, TNF-alpha.
Received: May 25, 2015 Accepted: Jul 4, 2016