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:: Volume 10, Issue 2 (9-2005) ::
SJKU 2005, 10(2): 1-9 Back to browse issues page
اثر تزریق داخل هیپوکمپی وراپامیل در روند ایجاد کیندلینگ شیمیایی بر روی یاد گیری فضایی در ماز آبی موریس در موشهای صحرایی
M.R Palizvan Dr 1, E Ghaznavi 2, A Amini Komijani 2
1- . Assistant Professor , palizvan@yahoo.com
2- . Instructor
Abstract:   (12375 Views)


 Background and Aim: In this study the effect of voltage dependent calcium channels of the CA1 region of the hippocampus on the pentylenetetrazol (PTZ) induced kindling and resultant learning deficits were investigated in rats.

 Materials and Methods: In this study the rats were divided into three groups. In the control group artificial cerebrospinal fluid (ACSF) was infused bilaterally into the hippocampus. In the kindled group, 20 min after infusion of ACSF, kindling was established in rats by injection of subconvulsive dose (37.5 mg/kg i.p.) of PTZ intraperitoneally. The rats were kept under observation for 20 minutes and the convulsive responses were graded on the basis of a 5-scale criterion. In the test or verapamile group, verapamile, were injected in the hippocampus (4 m g/4 min) and after 20 min Kindling was established in rats by use of PTZ. One month after induction of kindling spatial learning and memory were tested by Morris water maze in all three groups.

 Results: Theresults of this study were suggestive of a significant decrease of spatial learning in the rats of the test group.

 Conclusion: In this research, intera-hippcampal injection of verapamil significantly impaired spatial learning in rats.

Key words: Pentylenetetrazol, Kindling, Verapamil, Hippocampus, Spatial learning
Full-Text [PDF 204 kb]   (1016 Downloads)    
Type of Study: Research | Subject: General
Received: 2010/01/23
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Volume 10, Issue 2 (9-2005) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
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