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SJKU 2006, 10(4): 20-25 Back to browse issues page
Pregnancy after kidney transplantation. A survey in renal transplantation center of Kermanshah University of Medical Sciences
A Seyedzadeh Dr 1, D Reissi Dr2, N Rezavand Dr2
1- Assistant Professor , aseyedzadeh2001@yahoo.com
2- Assistant Professor
Abstract:   (13443 Views)


Background and Aim:

after Kidney transplantation. However, in such pregnancies, potential risks of

immunosuppressive agents on pregnancy status and fetus should be taken into

consideration. There are some reports indicating fetal malformations, preterm labour,

abortion and intrauterine growth retardation in such pregnancies. The present study

was designed to evaluate the status of pregnancy in women with kidney

transplantation in Renal Transplantation Center of the 4


Women with chronic renal failure can resume normal fertilityth Shahid Mehrab Hospital in

Materials and Methods:

records of women who had pregnancy after renal transplantation during 1368-1378

were reviewed. Necessary data concerning the serum creatinine level, blood pressure

during pregnancy, age at the time of pregnancy, interval between transplantation and

child-birth and occurrence of acute allograft rejection during pregnancy were

collected. The newborns were examined twice in a 6 month interval for physical

growth, developmental status and major malformations.

This was a descriptive-analytic study and the medical


case led to abortion (9%). Immunosuppressive therapy consisted of cyclosporin A

and steroid in 3 cases (30%), and cyclosporin A, steroid and azathioprine in 7 cases

(70%). The time interval between transplantation and childbirth was 24.6±15.67

months, and the mean age of mothers during pregnancy was 27.22±5.74 years. There

was no significant difference between mean systolic and diastolic blood pressures and

serum creatinine level before and during pregnancy. There was no acute allograft

rejection or any other remarkable problems during pregnancy. Only four newborns, 3

boys and one girl were brought for follow up. 3 cases of pregnancies were unwanted

and only one case was intentional. The mean weight of the newborns was 2.62±0.47

Kg, and one of them was underweight (25%). Physical growth and development of

these newborns were normal and there was no obvious congenital malformation.

11 pregnancies occurred in 9 women with kidney transplantation, , but one


expose mother and fetus to potential risks, this study like other recent studies revealed

that supportive measures before pregnancy and close monitoring of the pregnant

women by an experienced and multidisciplinary team, may lead to the birth of a

healthy baby, without any adverse effect on the function of the allograft

Although immunosuppressive agents can cross placental barrier and
Keywords: Kidney transplantation, Pregnancy, Infant, Neonate
Full-Text [PDF 105 kb]   (1841 Downloads)    
Type of Study: Research | Subject: General
Received: 2009/11/9
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Volume 10, Issue 4 (scientific journal of kurdistan university of medical sicences 2006) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
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