[Home ] [Archive]   [ فارسی ]  
:: Volume 14, Issue 2 (Scientific journal of Medical Sciences 2009) ::
SJKU 2009, 14(2): 21-30 Back to browse issues page
Comparative efficacy of deferrioxamin and combination of deferiprone and deferrioxamine on echocardiographic indices in beta thalassemic patients
Farzad Kompany Dr1, Shilan Mohammadi Dr * 2, Naseh Sigari Dr1, Nooshin Hadizadeh Dr1, Nazila Rezaie Dr, Fardin Gharibi
1- Assistant Professor
2- Resident , shilanmohammadi@yahoo.com
Abstract:   (12157 Views)
ABSTRACT Background and Aim: Regular blood transfusions in beta thalassemic patients can lead to accumulation of extra iron in the body which may result in cardiac complications and death. Deferrioxamin (DFO) is the standard treatment for this condition but 12-8 hours subcutaneous (SQ) injection of this drug per day can cause local pain which together with lack of patients´ compliance, it is necessary to use another drug to improve the condition of the patients. Deferiprone (DFP), is an approved drug for this purpose and removes iron from cells including cardiac muscle cells. The aim of this study is to compare efficacy of deferrioxamin with that of combined deferiprone and deferrioxamin on echocardiographic indices in beta thalassemic patients. Material and Methods: In this randomized clinical trial 40 thalassemic patients who met the inclusion criteria of this study were divided into two equal groups. Controls group received SQ deferrioxamin for six days/week and intervention group received deferrioxamin for three days/week and deferiprone orally for four days/week. Cardiac indices were measured and compared before and after the study. Results: Mean values of the age of the patients were 15.65.1 and 14.16 years in the intervention and control group respectively. Right ventricle diameter (RVD) indices in control group was 18.77.6 and 20.86.6 mm before and after treatment respectively (P<0.05). In the intervention group RVD indices were 19.55.8 and 18.0 4.7 mm before and after treatment respectively (P>0.05). Other indices such as LVEDD, LVESD, aortic root diameter, EF and Fs of left ventricle and also indices of the heart valves revealed no significant differences between the two groups. We didn’t observe any side effect of the drugs in the patients. Conclusion: We concluded combined therapy with 4 days DFP and 3 days DFO per week did not lead to cardiac complications and deterioration of echocardiographic indices. Key words: Major thalassemia, Deferrioxamin, Deferiprone, Echocardiographic indices. Conflict of Interest: Nill Received: May 25, 2009 Accepted: August 11, 2009
Keywords: Major thalassemia, Deferrioxamin, Deferiprone, Echocardiographic indices
Full-Text [PDF 164 kb]   (1192 Downloads)    
Type of Study: Research | Subject: General
Received: 2009/10/26
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA code


XML   Persian Abstract   Print



Volume 14, Issue 2 (Scientific journal of Medical Sciences 2009) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
Persian site map - English site map - Created in 0.07 seconds with 30 queries by YEKTAWEB 3731